Ma Peihua, Zhang Zhi, Tsai Shawn, Zhang Hongchao, Li Yuan, Yuan Fang, Wang Qin
Department of Nutrition and Food Science, College of Agriculture and Natural Resources, University of Maryland, College Park, MD 20740, USA.
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Laboratory for Food Quality and Safety, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China.
Foods. 2021 Mar 3;10(3):523. doi: 10.3390/foods10030523.
The ultrasound-assisted preparation of a curcumin-loaded metal organic framework (MOF) UiO-66-NH stabilized Pickering emulsion system was carried out in this study. A 3-level-4-factor Box-Behnken design (BBD) and response surface methodology (RSM) analysis were employed to systematically evaluate the effect of different experimental parameters (i.e., ultrasonic power, ultrasonic time, oil content, and MOF content) on curcumin loading capacity (LC) and encapsulation efficiency (EE). The results indicated that ultrasonic power and MOF content significantly affected LC and EE, whereas ultrasonic time and oil content had little effect. A mathematical model for optimizing the preparation of emulsion systems was established. Based on the ridge max analysis, an optimal condition for the newly developed curcumin-loaded MOF-Pickering emulsion was identified, i.e., ultrasonic power 150 W, ultrasonic time 11.17 min, oil content 20.0%, and MOF content 1.10%. At this condition, the LC and EE of curcumin obtained from the experiment reached 7.33% ± 0.54% and 56.18% ± 3.03%, respectively, which were within the prediction range of LC (7.35% ± 0.29%) and EE (54.34% ± 2.45%). The emulsion systems created in this study may find new applications for the delivery of bioactive compounds in food and pharmaceutical areas.
本研究开展了超声辅助制备负载姜黄素的金属有机框架材料（MOF）UiO - 66 - NH稳定的皮克林乳液体系。采用三水平四因素的Box - Behnken设计（BBD）和响应面法（RSM）分析，系统评估不同实验参数（即超声功率、超声时间、油含量和MOF含量）对姜黄素负载量（LC）和包封率（EE）的影响。结果表明，超声功率和MOF含量对LC和EE有显著影响，而超声时间和油含量影响较小。建立了优化乳液体系制备的数学模型。基于岭脊最大值分析，确定了新开发的负载姜黄素的MOF - 皮克林乳液的最佳条件，即超声功率150 W、超声时间11.17 min、油含量20.0%和MOF含量1.10%。在此条件下，实验得到的姜黄素LC和EE分别达到7.33% ± 0.54%和56.18% ± 3.03%，均在LC（7.35% ± 0.29%）和EE（54.34% ± 2.45%）的预测范围内。本研究中制备的乳液体系可能在食品和制药领域生物活性化合物的递送方面找到新的应用。
