Independent Unit of Experimental Neuropathophysiology, Medical University of Lublin, Jaczewskiego 8b, PL-20-090 Lublin, Poland.
Int J Mol Sci. 2021 Mar 3;22(5):2521. doi: 10.3390/ijms22052521.
Depression coexists with epilepsy, worsening its course. Treatment of the two diseases enables the possibility of interactions between antidepressant and antiepileptic drugs. The aim of this review was to analyze such interactions in one animal seizure model-the maximal electroshock (MES) in mice. Although numerous antidepressants showed an anticonvulsant action, mianserin exhibited a proconvulsant effect against electroconvulsions. In most cases, antidepressants potentiated or remained ineffective in relation to the antielectroshock action of classical antiepileptic drugs. However, mianserin and trazodone reduced the action of valproate, phenytoin, and carbamazepine against the MES test. Antiseizure drug effects were potentiated by all groups of antidepressants independently of their mechanisms of action. Therefore, other factors, including brain-derived neurotrophic factor (BDNF) and glial-derived neurotrophic factor (GDNF) modulation, should be considered as the background for the effect of drug combinations.
抑郁与癫痫并存，使病情恶化。两种疾病的治疗使得抗抑郁药和抗癫痫药之间可能发生相互作用。本综述的目的是分析一种动物癫痫模型——最大电休克（MES）中抗抑郁药与抗癫痫药之间的相互作用。虽然许多抗抑郁药具有抗惊厥作用，但米氮平对电惊厥表现出促惊厥作用。在大多数情况下，抗抑郁药增强或保持与经典抗癫痫药的抗电休克作用无关。然而，米氮平和曲唑酮降低了丙戊酸钠、苯妥英和卡马西平对 MES 试验的作用。抗惊厥药物的作用通过所有组别的抗抑郁药增强，而与它们的作用机制无关。因此，其他因素，包括脑源性神经营养因子（BDNF）和神经胶质源性神经营养因子（GDNF）的调节，应被视为药物组合作用的背景。
