Banks W A, Kastin A J
Section of Medicine, Veterans Administration Medical Center, New Orleans, LA.
Neurobiol Aging. 1988 Jan-Feb;9(1):48-9. doi: 10.1016/s0197-4580(88)80018-6.
Peptides can influence numerous systems known to be altered by aging. They can affect the passage of non-peptide substances across the blood-brain barrier (BBB) and themselves can cross by both saturable and non-saturable transport mechanisms. The passage of peptides across the BBB is influenced by numerous physiological and pathological events, including aging. Taken together, the evidence suggests that alterations in peptide/BBB interactions may play a significant role in senescence.
肽可以影响许多已知会因衰老而改变的系统。它们可以影响非肽类物质穿过血脑屏障（BBB），并且自身可以通过可饱和和不可饱和的转运机制穿过。肽穿过血脑屏障受到包括衰老在内的许多生理和病理事件的影响。综合来看，证据表明肽与血脑屏障相互作用的改变可能在衰老过程中起重要作用。
