Noureen Mehwish, Kawashima Takeshi, Arita Masanori
Department of Genetics, SOKENDAI University, Yata 1111, Mishima 411-8540, Shizuoka, Japan.
Bioinformation and DDBJ Center, National Institute of Genetics, Yata 1111, Mishima 411-8540, Shizuoka, Japan.
Microorganisms. 2021 Mar 17;9(3):621. doi: 10.3390/microorganisms9030621.
exhibits a diverse genomic structure with high mutation and recombination rates. Various genetic elements function as drivers of this genomic diversity including genome rearrangements. Identifying the association of these elements with rearrangements can pave the way to understand its genome evolution. We analyzed the order of orthologous genes among 72 publicly available complete genomes to identify large genome rearrangements, and rearrangement breakpoints were compared with the positions of insertion sequences, genomic islands, and restriction modification genes. Comparison of the shared inversions revealed the conserved genomic elements across strains from different geographical locations. Some were region-specific and others were global, indicating that highly shared rearrangements and their markers were more ancestral than strain-or region-specific ones. The locations of genomic islands were an important factor for the occurrence of the rearrangements. Comparative genomics helps to evaluate the conservation of various elements contributing to the diversity across genomes.
呈现出具有高突变率和重组率的多样基因组结构。各种遗传元件作为这种基因组多样性的驱动因素发挥作用，包括基因组重排。确定这些元件与重排之间的关联可为理解其基因组进化铺平道路。我们分析了72个公开可用的完整基因组中直系同源基因的顺序，以识别大型基因组重排，并将重排断点与插入序列、基因组岛和限制修饰基因的位置进行比较。共享倒位的比较揭示了来自不同地理位置菌株间保守的基因组元件。有些是区域特异性的，有些是全局性的，这表明高度共享的重排及其标记比重排或区域特异性的重排及其标记更具祖先特征。基因组岛的位置是重排发生的一个重要因素。比较基因组学有助于评估导致基因组多样性的各种元件的保守性。
