Morales F R, Engelhardt J K, Pereda A E, Yamuy J, Chase M H
Brain Research Institute, University of California, Los Angeles 90024.
Neurosci Lett. 1988 Apr 12;86(3):289-95. doi: 10.1016/0304-3940(88)90498-3.
The present study was undertaken to determine whether the postsynaptic inhibition of motoneurons that occurs following the pontine microinjection of carbachol in the decerebrate cat is due to the activity of Renshaw cells. Thirty-two out of 37 Renshaw cells (86%) were spontaneously active prior to the administration of carbachol, whereas only 2 out of 13 Renshaw cells (15%) discharged during carbachol-induced motor inhibition. In addition, discrete inhibitory synaptic potentials were observed in 33% of the Renshaw cells from which intracellular recordings were obtained after carbachol administration, indicating that these cells were actively inhibited. The finding that a population of Renshaw cells, which inhibit motoneurons, were themselves inhibited during a period of profound motoneuron inhibition was quite unexpected. These results support the conclusion that Renshaw cells are not the inhibitory interneurons that are responsible for the powerful inhibition of motoneurons that occurs following the pontine microinjection of carbachol.
本研究旨在确定在去大脑猫脑桥微量注射卡巴胆碱后运动神经元出现的突触后抑制是否归因于闰绍细胞的活动。在注射卡巴胆碱之前，37个闰绍细胞中有32个（86%）自发活动，而在卡巴胆碱诱导的运动抑制期间，13个闰绍细胞中只有2个（15%）放电。此外，在注射卡巴胆碱后进行细胞内记录的闰绍细胞中，33%观察到离散的抑制性突触电位，表明这些细胞被主动抑制。在运动神经元深度抑制期间，一群抑制运动神经元的闰绍细胞自身被抑制，这一发现相当出乎意料。这些结果支持以下结论：闰绍细胞不是负责脑桥微量注射卡巴胆碱后运动神经元强力抑制的抑制性中间神经元。
