Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY 12208, USA.
Admera Health, South Plainfield, NJ 07080, USA.
Molecules. 2021 Mar 9;26(5):1479. doi: 10.3390/molecules26051479.
Bioconjugation has allowed scientists to combine multiple functional elements into one biological or biochemical unit. This assembly can result in the production of constructs that are targeted to a specific site or cell type in order to enhance the response to, or activity of, the conjugated moiety. In the case of cancer treatments, selectively targeting chemotherapies to the cells of interest limit harmful side effects and enhance efficacy. Targeting through conjugation is also advantageous in delivering treatments to difficult-to-reach tissues, such as the brain or infections deep in the lung. Bacterial infections can be more selectively treated by conjugating antibiotics to microbe-specific entities; helping to avoid antibiotic resistance across commensal bacterial species. In the case of vaccine development, conjugation is used to enhance efficacy without compromising safety. In this work, we will review the previously mentioned areas in which bioconjugation has created new possibilities and advanced treatments.
生物共轭技术使得科学家们能够将多个功能元件组合成一个生物或生化单元。这种组装可以产生针对特定部位或细胞类型的构建物，以增强共轭部分的反应或活性。在癌症治疗的情况下，将化疗药物选择性地靶向感兴趣的细胞可以限制有害的副作用并提高疗效。通过共轭进行靶向治疗在向难以到达的组织（如大脑或肺部深处的感染）输送治疗方面也具有优势。通过将抗生素与微生物特异性实体共轭，可以更有选择性地治疗细菌感染，有助于避免共生细菌物种的抗生素耐药性。在疫苗开发方面，共轭技术用于在不影响安全性的情况下提高疗效。在这项工作中，我们将回顾生物共轭技术在创造新可能性和推进治疗方面的上述领域。
