Frotscher M
Institute of Anatomy, Johann Wolfgang Goethe University, Frankfurt am Main, F.R.G.
Neurosci Lett. 1988 Apr 22;87(1-2):18-22. doi: 10.1016/0304-3940(88)90138-3.
In recent studies a small number of choline acetyltransferase (ChAT)-immunoreactive, supposedly cholinergic, neurons intrinsic to the rat hippocampus have been described. Here we report that these neurons are not capable of sprouting in response to removal of the cholinergic input to the hippocampus from the medial septum/diagonal band complex. One month after unilateral transection of the fimbria-fornix an almost complete lack of cholinergic fibers persists in all layers of the dorsal hippocampus and fascia dentata ipsilateral to the lesion when compared to the contralateral hippocampus or to unlesioned control rats. These results indicate that the well-known phenomenon of collateral sprouting in response to partial deafferentation is a specific process that spares a distinct group of cholinergic cells in the rat hippocampus.
在最近的研究中，已经描述了大鼠海马体中少量胆碱乙酰转移酶（ChAT）免疫反应阳性、推测为胆碱能的内在神经元。在此我们报告，这些神经元不能因内侧隔区/斜角带复合体对海马体胆碱能输入的去除而发生芽生。与对侧海马体或未损伤的对照大鼠相比，在单侧切断穹窿-海马伞一个月后，损伤同侧的背侧海马体和齿状回各层中几乎完全缺乏胆碱能纤维。这些结果表明，响应部分去传入而出现的侧支芽生这一众所周知的现象是一个特定过程，该过程使大鼠海马体中一组独特的胆碱能细胞得以保留。
