洞察阿利西定与次氯酸钠的反应：牙髓治疗中的潜在错误。
Insight into the Reaction of Alexidine with Sodium Hypochlorite: A Potential Error in Endodontic Treatment.
机构信息
Jagiellonian University Medical College, Faculty of Medicine, Institute of Stomatology, Department of Conservative Dentistry with Endodontics, Montelupich 4, 30-155 Kraków, Poland.
Laboratory for Forensic Chemistry, Department of Analytical Chemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Kraków, Poland.
出版信息
Molecules. 2021 Mar 15;26(6):1623. doi: 10.3390/molecules26061623.
Therapeutic success in endodontic treatment depends on successful infection control. Alexidine dihydrochloride (ALX) was recently proposed as a potential alternative to 2% chlorhexidine (CHX) as it possesses similar antimicrobial properties, expresses substantivity and does not produce p-chloroaniline (PCA) when mixed with sodium hypochlorite (NaOCl). However, the products released in this reaction have not been described to date. The aim of this study was to identify detected chemical compounds formed in the reaction of ALX and NaOCl with the ultra-high-performance liquid chromatography-mass spectrophotometry (UHPLC-MS) method and assess whether precipitates and PCA are formed in this reaction. Solutions of ALX were mixed with the equivalent volume of 2% and 5.25% (/) NaOCl solutions. As control, 2% (/) CHX was mixed with 2% and 5.25% (/) NaOCl. Samples were subjected to the UHPLC-MS analysis. The mixture of ALX and NaOCl resulted in a yellowish precipitate formation, the amount of which depended on NaOCl concentration. Interaction of ALX and NaOCl resulted in the production of aliphatic amines. No PCA was formed when NaOCl was mixed with ALX. However, for the first time, we identified the possible products of the interaction. The interaction between NaOCl and ALX results in the formation of aliphatic amines; therefore, these compounds should not be mixed during endodontic treatment.
根管治疗的成功取决于成功的感染控制。盐酸阿来昔定（ALX）最近被提议作为 2%洗必泰（CHX）的潜在替代品，因为它具有相似的抗菌性能，表达了固着性，并且当与次氯酸钠（NaOCl）混合时不会产生对氯苯胺（PCA）。然而，迄今为止尚未描述该反应中释放的产物。本研究的目的是使用超高效液相色谱-质谱联用（UHPLC-MS）方法鉴定 ALX 和 NaOCl 反应中形成的检测到的化学化合物，并评估该反应中是否形成沉淀物和 PCA。将 ALX 溶液与等体积的 2%和 5.25%（/）NaOCl 溶液混合。作为对照，将 2%（/）CHX 与 2%和 5.25%（/）NaOCl 混合。对样品进行 UHPLC-MS 分析。ALX 和 NaOCl 的混合物形成了淡黄色沉淀物，其数量取决于 NaOCl 浓度。ALX 和 NaOCl 的相互作用导致脂肪胺的产生。当 NaOCl 与 ALX 混合时没有形成 PCA。然而，我们首次确定了相互作用的可能产物。NaOCl 和 ALX 之间的相互作用导致脂肪胺的形成；因此，在根管治疗过程中不应混合这些化合物。
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