Humberstone D A, Shaw J H
University Department of Surgery, Auckland Hospital.
N Z Med J. 1988 Feb 10;101(839):41-3.
We have reviewed the records of 105 patients with the diagnosis of soft tissue sarcoma seen in the Auckland region between January 1974 and December 1984. The mean age at diagnosis was 54 years and the average duration of symptoms prior to specialist assessment was 8 months. By the time of presentation 27% of patients had metastatic disease. Forty-six patients underwent biopsy-type procedures and of these only one patient was alive and apparently disease free at one year. Three were alive with disease at an average of 2.2 years, 29 of the 46 had died of their sarcoma at one year and five of the 46 died of other causes. Fifty nine patients had definitive reactions performed and 26 of were alive with disease at an average of 2.2 years, 29 of the 46 had died of their sarcoma at one year and five of the 46 died of these were alive and disease free at two years. Six were alive with recurrent disease and 15 had died of sarcoma 1.9 years after presentation. In terms of site of the primary, patients with limb sarcomas fared better than those with retroperitoneal lesions, whereas sarcomas in other locations had survival figures in between these two groups. Soft tissue sarcomas consitute an aggressive and unforgiving type of cancer, and to entertain any realistic chance of cure complete resection of the lesion must be achieved. However, the patients presented to specialist attention at a relatively late stage of their disease, and the chances of survival are dependent both on the site of the primary lesion and on whether or not definitive surgery and adjuvant therapy is employed.
我们回顾了1974年1月至1984年12月间在奥克兰地区确诊为软组织肉瘤的105例患者的病历。确诊时的平均年龄为54岁,在接受专科评估之前症状的平均持续时间为8个月。就诊时27%的患者已有转移性疾病。46例患者接受了活检类手术,其中只有1例患者在1年后存活且显然无疾病。3例患者带瘤存活,平均存活2.2年,46例中有29例在1年后死于肉瘤,46例中有5例死于其他原因。59例患者进行了确定性手术,其中26例带瘤存活,平均存活2.2年,46例中有29例在1年后死于肉瘤,46例中有5例在2年后存活且无疾病。6例患者复发存活,15例在就诊1.9年后死于肉瘤。就原发部位而言,肢体肉瘤患者的预后优于腹膜后病变患者,而其他部位的肉瘤患者的生存数据介于这两组之间。软组织肉瘤是一种侵袭性且难以治愈的癌症类型,要想有任何实际的治愈机会,必须实现病变的完全切除。然而,这些患者在疾病相对较晚阶段才引起专科医生的注意,生存机会既取决于原发病变的部位,也取决于是否采用了确定性手术和辅助治疗。