Cho Byung Woo, Kim Du Seong, Kwon Hyuck Min, Yang Ick Hwan, Lee Woo-Suk, Park Kwan Kyu
Department of Orthopaedic Surgery, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.
Department of Orthopaedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul 06273, Korea.
J Clin Med. 2021 Mar 1;10(5):933. doi: 10.3390/jcm10050933.
Few studies have reported the relationship between knee pain and hypercholesterolemia in the elderly population with osteoarthritis (OA), independent of other variables. The aim of this study was to reveal the association between knee pain and metabolic diseases including hypercholesterolemia using a large-scale cohort. A cross-sectional study was conducted using data from the Korea National Health and the Nutrition Examination Survey (KNHANES-V, VI-1; 2010-2013). Among the subjects aged ≥60 years, 7438 subjects (weighted number estimate = 35,524,307) who replied knee pain item and performed the simple radiographs of knee were enrolled. Using multivariable ordinal logistic regression analysis, variables affecting knee pain were identified, and the odds ratio (OR) was calculated. Of the 35,524,307 subjects, 10,630,836 (29.9%) subjects experienced knee pain. Overall, 20,290,421 subjects (56.3%) had radiographic OA, and 8,119,372 (40.0%) of them complained of knee pain. Multivariable ordinal logistic regression analysis showed that among the metabolic diseases, only hypercholesterolemia was positively correlated with knee pain in the OA group (OR 1.24; 95% Confidence Interval 1.02-1.52, = 0.033). There were no metabolic diseases correlated with knee pain in the non-OA group. This large-scale study revealed that in the elderly, hypercholesterolemia was positively associated with knee pain independent of body mass index and other metabolic diseases in the OA group, but not in the non-OA group. These results will help in understanding the nature of arthritic pain, and may support the need for exploring the longitudinal associations.
很少有研究报道在患有骨关节炎（OA）的老年人群中，膝关节疼痛与高胆固醇血症之间的关系，且不受其他变量影响。本研究的目的是通过大规模队列研究揭示膝关节疼痛与包括高胆固醇血症在内的代谢性疾病之间的关联。利用韩国国家健康与营养检查调查（KNHANES-V、VI-1；2010 - 2013年）的数据进行了一项横断面研究。在年龄≥60岁的受试者中，纳入了7438名回答了膝关节疼痛问题并进行了膝关节简单X线检查的受试者（加权估计人数 = 35524307）。采用多变量有序逻辑回归分析，确定影响膝关节疼痛的变量，并计算优势比（OR）。在35524307名受试者中，10630836名（29.9%）受试者经历过膝关节疼痛。总体而言，20290421名受试者（56.3%）有影像学诊断的OA，其中8119372名（40.0%）主诉膝关节疼痛。多变量有序逻辑回归分析显示，在代谢性疾病中，仅高胆固醇血症与OA组的膝关节疼痛呈正相关（OR 1.24；95%置信区间1.02 - 1.52，P = 0.033）。在非OA组中，没有代谢性疾病与膝关节疼痛相关。这项大规模研究表明，在老年人中，高胆固醇血症与OA组的膝关节疼痛呈正相关，且独立于体重指数和其他代谢性疾病，但在非OA组中并非如此。这些结果将有助于理解关节炎疼痛的本质，并可能支持探索纵向关联的必要性。
