The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine (Shandong Hospital of integrated traditional Chinese and Western medicine), Jinan, China.
Front Endocrinol (Lausanne). 2024 Apr 19;15:1352671. doi: 10.3389/fendo.2024.1352671. eCollection 2024.
Osteoarthritis is the most prevalent age-related degenerative joint disease and a leading cause of pain and disability in aged people. Its etiology is multifaceted, involving factors such as biomechanics, pro-inflammatory mediators, genetics, and metabolism. Beyond its evident impact on joint functionality and the erosion of patients' quality of life, OA exhibits symbiotic relationships with various systemic diseases, giving rise to various complications. This review reveals OA's extensive impact, encompassing osteoporosis, sarcopenia, cardiovascular diseases, diabetes mellitus, neurological disorders, mental health, and even cancer. Shared inflammatory processes, genetic factors, and lifestyle elements link OA to these systemic conditions. Consequently, recognizing these connections and addressing them offers opportunities to enhance patient care and reduce the burden of associated diseases, emphasizing the need for a holistic approach to managing OA and its complications.
骨关节炎是最常见的与年龄相关的退行性关节疾病，也是老年人疼痛和残疾的主要原因。其病因是多方面的，涉及生物力学、促炎介质、遗传和代谢等因素。除了对关节功能的明显影响和患者生活质量的侵蚀外，OA 还与各种全身性疾病存在共生关系，引发各种并发症。本综述揭示了 OA 的广泛影响，包括骨质疏松症、肌肉减少症、心血管疾病、糖尿病、神经紊乱、心理健康，甚至癌症。共同的炎症过程、遗传因素和生活方式因素将 OA 与这些系统性疾病联系在一起。因此，认识到这些联系并加以解决，为改善患者的护理和减轻相关疾病的负担提供了机会，强调了采用整体方法来管理 OA 及其并发症的必要性。
