Gangitano Elena, Tozzi Rossella, Gandini Orietta, Watanabe Mikiko, Basciani Sabrina, Mariani Stefania, Lenzi Andrea, Gnessi Lucio, Lubrano Carla
Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.
Nutrients. 2021 Mar 20;13(3):1004. doi: 10.3390/nu13031004.
Severe obesity is associated with an increased risk of admission to intensive care units and need for invasive mechanical ventilation in patients with COVID-19. The association of obesity and COVID-19 prognosis may be related to many different factors, such as chronic systemic inflammation, the predisposition to severe respiratory conditions and viral infections. The ketogenic diet is an approach that can be extremely effective in reducing body weight and visceral fat in the short term, preserving the lean mass and reducing systemic inflammation. Therefore, it is a precious preventive measure for severely obese people and may be considered as an adjuvant therapy for patients with respiratory compromise.
重度肥胖与新冠肺炎患者入住重症监护病房的风险增加以及有创机械通气需求有关。肥胖与新冠肺炎预后的关联可能与许多不同因素有关,如慢性全身性炎症、易患严重呼吸道疾病和病毒感染。生酮饮食是一种在短期内可极其有效地减轻体重和内脏脂肪、保留瘦体重并减轻全身性炎症的方法。因此,它是重度肥胖者的一项宝贵预防措施,并且可被视为呼吸功能受损患者的辅助治疗方法。