大麻、大麻二酚油和四氢大麻酚——兽医需要了解什么？
Cannabis, Cannabidiol Oils and Tetrahydrocannabinol-What Do Veterinarians Need to Know?
作者信息
De Briyne Nancy, Holmes Danny, Sandler Ian, Stiles Enid, Szymanski Dharati, Moody Sarah, Neumann Stephan, Anadón Arturo
机构信息
Federation of Veterinarians of Europe (FVE), 1040 Brussels, Belgium.
Holmes St Anthony's Veterinary Hospital, St Anthonys, Caherslee, V92 V6YK Tralee, Ireland.
出版信息
Animals (Basel). 2021 Mar 20;11(3):892. doi: 10.3390/ani11030892.
Abstract
As cannabis-derived products have become more available, veterinarians are seeing more cases of toxicosis. In addition, animal owners are having an increasing interest in using these products for their pets. This review looks at the situation in Europe and North America, the different types of cannabis and cannabis-derived products with historical examples of use in animals, and the cannabis industry. The existing regulatory framework for use in humans and animals as medicines and/or supplements was examined. Finally, a review of the clinical indications for which medicinal cannabis is authorised, a discussion of toxicosis, and recommendations and warnings around medical cannabis use are presented.
摘要
随着大麻衍生产品越来越容易获得，兽医们见到的中毒病例也越来越多。此外，宠物主人对在宠物身上使用这些产品的兴趣也日益浓厚。这篇综述探讨了欧洲和北美的情况、不同类型的大麻及大麻衍生产品，并列举了其在动物身上使用的历史实例，还介绍了大麻产业。研究了现有的关于人类和动物使用大麻作为药品和/或补充剂的监管框架。最后，介绍了药用大麻被批准使用的临床适应症，讨论了中毒情况，并给出了关于药用大麻使用的建议和警告。
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本文引用的文献
1
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J Am Anim Hosp Assoc. 2021 Mar 1;57(2):81-90. doi: 10.5326/JAAHA-MS-7119.
2
Pharmacokinetic and Safety Evaluation of Various Oral Doses of a Novel 1:20 THC:CBD Herbal Extract in Dogs.
Front Vet Sci. 2020 Sep 29;7:583404. doi: 10.3389/fvets.2020.583404. eCollection 2020.
3
Hemp in Veterinary Medicine: From Feed to Drug.
Front Vet Sci. 2020 Jul 28;7:387. doi: 10.3389/fvets.2020.00387. eCollection 2020.
4
Critical Aspects Affecting Cannabidiol Oral Bioavailability and Metabolic Elimination, and Related Clinical Implications.
CNS Drugs. 2020 Aug;34(8):795-800. doi: 10.1007/s40263-020-00741-5.
5
Cannabinoid, Terpene, and Heavy Metal Analysis of 29 Over-the-Counter Commercial Veterinary Hemp Supplements.
Vet Med (Auckl). 2020 Apr 15;11:45-55. doi: 10.2147/VMRR.S248712. eCollection 2020.
6
A randomized, double-blind, placebo-controlled study of daily cannabidiol for the treatment of canine osteoarthritis pain.
Pain. 2020 Sep 1;161(9):2191-2202. doi: 10.1097/j.pain.0000000000001896.
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Preliminary Investigation of the Safety of Escalating Cannabinoid Doses in Healthy Dogs.
Front Vet Sci. 2020 Feb 11;7:51. doi: 10.3389/fvets.2020.00051. eCollection 2020.
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9
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10
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Epilepsia. 2019 Aug;60(8):1586-1592. doi: 10.1111/epi.16093. Epub 2019 Jun 27.
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