Schmidt Emma K A, Raposo Pamela J F, Madsen Karen L, Fenrich Keith K, Kabarchuk Gillian, Fouad Karim
Neuroscience and Mental Health Institute, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Biology (Basel). 2021 Mar 24;10(4):254. doi: 10.3390/biology10040254.
Spinal cord injury (SCI) causes gut dysbiosis and an increased prevalence of depression and anxiety. Previous research showed a link between these two consequences of SCI by using a fecal transplant from healthy rats which prevented both SCI-induced microbiota changes and the subsequent development of anxiety-like behaviour. However, whether the physical and mental state of the donor are important factors in the efficacy of FMT therapy after SCI remains unknown. In the present study, rats received a fecal transplant following SCI from uninjured donors with increased baseline levels of anxiety-like behaviour and reduced proportion of in their stool. This fecal transplant increased intestinal permeability, induced anxiety-like behaviour, and resulted in minor but long-term alterations in the inflammatory state of the recipients compared to vehicle controls. There was no significant effect of the fecal transplant on motor recovery in rehabilitative training, suggesting that anxiety-like behaviour did not affect the motivation to participate in rehabilitative therapy. The results of this study emphasize the importance of considering both the microbiota composition and the mental state of the donor for fecal transplants following spinal cord injury.
脊髓损伤（SCI）会导致肠道微生物群失调，并增加抑郁症和焦虑症的患病率。先前的研究通过使用来自健康大鼠的粪便移植，证明了SCI的这两种后果之间的联系，这种移植既能防止SCI引起的微生物群变化，又能防止随后类似焦虑行为的发展。然而，供体的身心状态是否是SCI后粪菌移植疗法疗效的重要因素仍不清楚。在本研究中，大鼠在脊髓损伤后接受了来自未受伤供体的粪便移植，这些供体具有较高的基线焦虑样行为水平，且其粪便中[此处原文缺失相关内容]的比例较低。与载体对照组相比，这种粪便移植增加了肠道通透性，诱发了焦虑样行为，并导致受体炎症状态出现轻微但长期的改变。粪便移植对康复训练中的运动恢复没有显著影响，这表明焦虑样行为不会影响参与康复治疗的积极性。本研究结果强调了在脊髓损伤后进行粪便移植时，考虑供体微生物群组成和精神状态的重要性。
