Théret Nathalie, Bouezzedine Fidaa, Azar Fida, Diab-Assaf Mona, Legagneux Vincent
Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en santé, Environnement et Travail)-UMR_S1085, University of Rennes 1, 35000 Rennes, France.
Molecular Cancer and Pharmaceutical Biology Laboratory, Faculty of Sciences II, Lebanese University Fanar, 1500 Beirut, Lebanon.
Cancers (Basel). 2021 Mar 29;13(7):1563. doi: 10.3390/cancers13071563.
The tumor microenvironment plays a major role in tumor growth, invasion and resistance to chemotherapy, however understanding how all actors from microenvironment interact together remains a complex issue. The tumor microenvironment is classically represented as three closely connected components including the stromal cells such as immune cells, fibroblasts, adipocytes and endothelial cells, the extracellular matrix (ECM) and the cytokine/growth factors. Within this space, proteins of the adamalysin family (ADAM for a disintegrin and metalloproteinase; ADAMTS for ADAM with thrombospondin motifs; ADAMTSL for ADAMTS-like) play critical roles by modulating cell-cell and cell-ECM communication. During last decade, the implication of adamalysins in the development of hepatocellular carcinoma (HCC) has been supported by numerous studies however the functional characterization of most of them remain unsettled. In the present review we propose both an overview of the literature and a meta-analysis of adamalysins expression in HCC using data generated by The Cancer Genome Atlas (TCGA) Research Network.
肿瘤微环境在肿瘤生长、侵袭及化疗耐药中起主要作用，然而，了解微环境中的所有成分如何相互作用仍是一个复杂的问题。传统上，肿瘤微环境由三个紧密相连的成分组成，包括免疫细胞、成纤维细胞、脂肪细胞和内皮细胞等基质细胞、细胞外基质（ECM）以及细胞因子/生长因子。在这个空间内，解整合素和金属蛋白酶家族（ADAM，即去整合素和金属蛋白酶；ADAMTS，即含血小板反应蛋白基序的ADAM；ADAMTSL，即类ADAMTS）的蛋白质通过调节细胞间和细胞与ECM的通讯发挥关键作用。在过去十年中，众多研究支持了解整合素和金属蛋白酶在肝细胞癌（HCC）发生发展中的作用，然而，其中大多数的功能特性仍未明确。在本综述中，我们利用癌症基因组图谱（TCGA）研究网络生成的数据，对文献进行了综述，并对HCC中解整合素和金属蛋白酶的表达进行了荟萃分析。
