壳聚糖对两亲性聚合物增溶的水溶性和疏水性卟啉光敏剂活性的影响

Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers.

作者信息

Kardumyan Valeriya V, Aksenova Nadejda A, Timofeeva Victoria A, Krivandin Alexey V, Shatalova Olga V, Dubovik Alexander S, Plashchina Irina G, Timashev Peter S, Solovieva Anna B

机构信息

N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119991, Russia.

Institute for Regenerative Medicine, Sechenov First Moscow State Medical University (Sechenov University), 8-2 Trubetskayast, Moscow 119991, Russia.

出版信息

Polymers (Basel). 2021 Mar 25;13(7):1007. doi: 10.3390/polym13071007.

DOI:10.3390/polym13071007

PMID:33805853

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8037264/

Abstract

In this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of chitosan (CT). Water-soluble compounds (dimegin and trisodium salt of chlorin e6 (Ce6)) and hydrophobic porphyrins (tetraphenylporphyrin (TPP) and its fluorine derivative (TPPF20)) were used as PSs. It was shown that the use of chitosan (Mw ~100 kDa) makes it possible to obtain a system whose activity is comparable to that of the photosensitizer-amphiphilic polymer systems. Thus, the previously observed drop in the photosensitizing activity of PS in the presence of a polysaccharide and amphiphilic polymers (AP) was absent in this case. At the same time, chitosan had practically no inhibitory effect on hydrophobic porphyrins solubilized by Pluronic F127.

摘要

在本研究中，我们考察了用聚乙烯吡咯烷酮（PVP）和三元嵌段共聚物环氧乙烷和环氧丙烷普朗尼克F127（F127）增溶的各种性质的光敏剂（PSs）在壳聚糖（CT）存在下水中色氨酸光氧化模型反应中的光催化活性。使用水溶性化合物（二甲基亚砜和氯e6三钠盐（Ce6））和疏水性卟啉（四苯基卟啉（TPP）及其氟衍生物（TPPF20））作为PSs。结果表明，使用壳聚糖（Mw~100 kDa）能够得到一个活性与光敏剂-两亲聚合物体系相当的体系。因此，在这种情况下不存在之前观察到的在多糖和两亲聚合物（AP）存在下PS光敏活性的下降。同时，壳聚糖对被普朗尼克F127增溶的疏水性卟啉几乎没有抑制作用。