Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
Nutrients. 2021 Mar 25;13(4):1065. doi: 10.3390/nu13041065.
Asthma physiology affects respiratory function and inflammation, factors that may contribute to elevated resting energy expenditure (REE) and altered body composition. We hypothesized that asthma would present with elevated REE compared to weight-matched healthy controls. Adults with asthma ( = 41) and healthy controls ( = 20) underwent indirect calorimetry to measure REE, dual-energy X-ray absorptiometry (DEXA) to measure body composition, and 3-day diet records. Clinical assessments included spirometry, fractional exhaled nitric oxide (FENO), and a complete blood count. Asthmatics had greater REE than controls amounting to an increase of ~100 kcals/day, even though body mass index (BMI) and body composition were similar between groups. Inclusion of asthma status and FENO in validated REE prediction equations led to improved estimates. Further, asthmatics had higher white blood cell (control vs. asthma (mean ± SD): 4.7 ± 1.1 vs. 5.9 ± 1.6, < 0.01) and neutrophil (2.8 ± 0.9 vs. 3.6 ± 1.4, = 0.02) counts that correlated with REE (both < 0.01). Interestingly, despite higher REE, asthmatics reported consuming fewer calories (25.1 ± 7.5 vs. 20.3 ± 6.0 kcals/kg/day, < 0.01) and carbohydrates than controls. REE is elevated in adults with mild asthma, suggesting there is an association between REE and the pathophysiology of asthma.
哮喘生理学影响呼吸功能和炎症，这些因素可能导致静息能量消耗（REE）升高和身体成分改变。我们假设哮喘患者的 REE 会高于体重匹配的健康对照组。41 名哮喘患者（）和 20 名健康对照组（）接受间接热量测定法以测量 REE，双能 X 射线吸收法（DEXA）以测量身体成分，以及 3 天饮食记录。临床评估包括肺量测定、呼出气一氧化氮分数（FENO）和全血细胞计数。哮喘患者的 REE 高于对照组，每天增加约 100 卡路里，尽管两组的体重指数（BMI）和身体成分相似。将哮喘状态和 FENO 纳入经过验证的 REE 预测方程可提高估计值。此外，哮喘患者的白细胞（对照组与哮喘组（平均值±标准差）：4.7±1.1 对 5.9±1.6，<0.01）和中性粒细胞（2.8±0.9 对 3.6±1.4，=0.02）计数较高，与 REE 相关（均<0.01）。有趣的是，尽管 REE 较高，但哮喘患者报告的卡路里摄入量（25.1±7.5 对 20.3±6.0 卡路里/公斤/天，<0.01）和碳水化合物摄入量低于对照组。轻度哮喘成人的 REE 升高，表明 REE 与哮喘的病理生理学之间存在关联。
