芳基钌(II)配合物，具有 κ-或 κ-,κ- PhP(CH)SPh 配体。
Arene Ruthenium(II) Complexes Bearing the κ- or κ-,κ- PhP(CH)SPh Ligand.
机构信息
Institute of Chemistry, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Straße 2, D-06120 Halle, Germany.
Institute for Biological Research "Sinisa Stankovic" National Institute of Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.
出版信息
Molecules. 2021 Mar 25;26(7):1860. doi: 10.3390/molecules26071860.
Neutral [Ru(η-arene)Cl{PhP(CH)SPh-κ}] (arene = benzene, indane, 1,2,3,4-tetrahydronaphthalene: , and ) and cationic [Ru(η-arene)Cl(PhP(CH)SPh-κ,κ)]X complexes (arene = mesitylene, 1,4-dihydronaphthalene; X = Cl: , ; arene = benzene, mesitylene, indane, 1,2,3,4-tetrahydronaphthalene, and 1,4-dihydronaphthalene; X = PF: -) complexes were prepared and characterized by elemental analysis, IR, H, C and P NMR spectroscopy and also by single-crystal X-ray diffraction analyses. The stability of the complexes has been investigated in DMSO. Complexes have been assessed for their cytotoxic activity against 518A2, 8505C, A253, MCF-7 and SW480 cell lines. Generally, complexes exhibited activity in the lower micromolar range; moreover, they are found to be more active than cisplatin. For the most active ruthenium(II) complex, , bearing mesitylene as ligand, the mechanism of action against 8505C cisplatin resistant cell line was determined. Complex induced apoptosis accompanied by caspase activation.
中性[Ru(η-芳基)Cl{PhP(CH)SPh-κ}]（芳基=苯、茚、1,2,3,4-四氢萘： ， 和 ）和阳离子[Ru(η-芳基)Cl(PhP(CH)SPh-κ,κ)]X 配合物（芳基=均三甲苯、1,4-二氢萘；X=Cl: ， ；芳基=苯、均三甲苯、茚、1,2,3,4-四氢萘和 1,4-二氢萘；X=PF: -）配合物通过元素分析、IR、H、C 和 P NMR 光谱以及单晶 X 射线衍射分析进行了制备和表征。在 DMSO 中研究了配合物的稳定性。评估了配合物对 518A2、8505C、A253、MCF-7 和 SW480 细胞系的细胞毒性活性。通常，配合物在较低的微摩尔范围内表现出活性；此外，它们比顺铂更有效。对于最活跃的钌(II)配合物 ，带有均三甲苯作为配体，确定了其对 8505C 顺铂耐药细胞系的作用机制。复合物 诱导细胞凋亡，伴随半胱天冬酶的激活。
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