Suppr超能文献

严重动脉狭窄处高度紊乱血流的频谱分解与声源定位

Spectral Decomposition and Sound Source Localization of Highly Disturbed Flow through a Severe Arterial Stenosis.

作者信息

Khalili Fardin, Gamage Peshala T, Taebi Amirtahà, Johnson Mark E, Roberts Randal B, Mitchel John

机构信息

Department of Mechanical Engineering, Embry-Riddle Aeronautical University, 1 Aerospace Boulevard, Daytona Beach, FL 32114, USA.

Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, 2930 Science Cir., Melbourne, FL 32901, USA.

出版信息

Bioengineering (Basel). 2021 Mar 4;8(3):34. doi: 10.3390/bioengineering8030034.

Abstract

For the early detection of atherosclerosis, it is imperative to explore the capabilities of new, effective noninvasive diagnosis techniques to significantly reduce the associated treatment costs and mortality rates. In this study, a multifaceted comprehensive approach involving advanced computational fluid dynamics combined with signal processing techniques was exploited to investigate the highly turbulent fluctuating flow through arterial stenosis. The focus was on localizing high-energy mechano-acoustic source potential to transmit to the epidermal surface. The flow analysis results showed the existence of turbulent pressure fluctuations inside the stenosis and in the post-stenotic region. After analyzing the turbulent kinetic energy and pressure fluctuations on the flow centerline and the vessel wall, the point of maximum excitation in the flow was observed around two diameters downstream of the stenosis within the fluctuating zone. It was also found that the concentration of pressure fluctuation closer to the wall was higher inside the stenosis compared to the post-stenotic region. Additionally, the visualization of the most energetic proper orthogonal decomposition (POD) mode and spectral decomposition of the flow indicated that the break frequencies ranged from 80 to 220 Hz and were correlated to the eddies generated within these regions.

摘要

为了早期检测动脉粥样硬化,探索新型有效非侵入性诊断技术的能力以显著降低相关治疗成本和死亡率势在必行。在本研究中,采用了一种多方面的综合方法,将先进的计算流体动力学与信号处理技术相结合,以研究通过动脉狭窄处的高度湍流脉动流。重点是定位能够传输到表皮表面的高能机械声源潜力。流动分析结果表明,在狭窄内部和狭窄后区域存在湍流压力波动。在分析了流动中心线和血管壁上的湍流动能和压力波动后,在波动区内狭窄下游约两个直径处观察到流动中最大激励点。还发现,与狭窄后区域相比,狭窄内部靠近壁面的压力波动浓度更高。此外,对最具能量的本征正交分解(POD)模式的可视化以及流动的频谱分解表明,断裂频率范围为80至220Hz,并且与这些区域内产生的涡流相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a6f/8000318/6899297acb51/bioengineering-08-00034-g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验