Khalili Fardin, Gamage Peshala T, Taebi Amirtahà, Johnson Mark E, Roberts Randal B, Mitchel John
Department of Mechanical Engineering, Embry-Riddle Aeronautical University, 1 Aerospace Boulevard, Daytona Beach, FL 32114, USA.
Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, 2930 Science Cir., Melbourne, FL 32901, USA.
Bioengineering (Basel). 2021 Mar 4;8(3):34. doi: 10.3390/bioengineering8030034.
For the early detection of atherosclerosis, it is imperative to explore the capabilities of new, effective noninvasive diagnosis techniques to significantly reduce the associated treatment costs and mortality rates. In this study, a multifaceted comprehensive approach involving advanced computational fluid dynamics combined with signal processing techniques was exploited to investigate the highly turbulent fluctuating flow through arterial stenosis. The focus was on localizing high-energy mechano-acoustic source potential to transmit to the epidermal surface. The flow analysis results showed the existence of turbulent pressure fluctuations inside the stenosis and in the post-stenotic region. After analyzing the turbulent kinetic energy and pressure fluctuations on the flow centerline and the vessel wall, the point of maximum excitation in the flow was observed around two diameters downstream of the stenosis within the fluctuating zone. It was also found that the concentration of pressure fluctuation closer to the wall was higher inside the stenosis compared to the post-stenotic region. Additionally, the visualization of the most energetic proper orthogonal decomposition (POD) mode and spectral decomposition of the flow indicated that the break frequencies ranged from 80 to 220 Hz and were correlated to the eddies generated within these regions.
为了早期检测动脉粥样硬化,探索新型有效非侵入性诊断技术的能力以显著降低相关治疗成本和死亡率势在必行。在本研究中,采用了一种多方面的综合方法,将先进的计算流体动力学与信号处理技术相结合,以研究通过动脉狭窄处的高度湍流脉动流。重点是定位能够传输到表皮表面的高能机械声源潜力。流动分析结果表明,在狭窄内部和狭窄后区域存在湍流压力波动。在分析了流动中心线和血管壁上的湍流动能和压力波动后,在波动区内狭窄下游约两个直径处观察到流动中最大激励点。还发现,与狭窄后区域相比,狭窄内部靠近壁面的压力波动浓度更高。此外,对最具能量的本征正交分解(POD)模式的可视化以及流动的频谱分解表明,断裂频率范围为80至220Hz,并且与这些区域内产生的涡流相关。