Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5166/15731, Iran.
Humanitas Clinical and Research Center-IRCCS, 20089 Milan, Italy.
Genes (Basel). 2021 Mar 23;12(3):455. doi: 10.3390/genes12030455.
Glioblastoma, also known as glioblastoma multiforme, is the most aggressive brain tumor in adults. Despite the huge advance in developing novel therapeutic strategies for patients with glioblastoma, the appearance of multidrug resistance (MDR) against the common chemotherapeutic agents, including temozolomide, is considered as one of the important causes for the failure of glioblastoma treatment. On the other hand, recent studies have demonstrated the critical roles of long non-coding RNAs (lncRNAs), particularly in the development of MDR in glioblastoma. Therefore, this article aimed to review lncRNA's contribution to the regulation of MDR and elucidate the underlying mechanisms in glioblastoma, which will open up new lines of inquiry in the treatment of glioblastoma.
胶质母细胞瘤，又称多形性胶质母细胞瘤，是成人中最具侵袭性的脑肿瘤。尽管在为胶质母细胞瘤患者开发新的治疗策略方面取得了巨大进展，但对包括替莫唑胺在内的常见化疗药物出现多药耐药（MDR）被认为是治疗失败的重要原因之一。另一方面，最近的研究表明，长链非编码 RNA（lncRNA），特别是在胶质母细胞瘤的 MDR 发展中具有关键作用。因此，本文旨在综述 lncRNA 在调节 MDR 中的作用，并阐明胶质母细胞瘤中潜在的机制，这将为胶质母细胞瘤的治疗开辟新的研究方向。
