帕金森病患者QTc间期延长的患病率。药物、临床危险因素及所用校正公式的影响评估。
Prevalence of QTc Prolongation in Patients with Parkinson's Disease. Assessment of the Effects of Drugs, Clinical Risk Factors and Used Correction Formula.
作者信息
Malkiewicz Jakub J, Malkiewicz Maciej, Siuda Joanna
机构信息
Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, University Clinical Center Prof. K. Gibiński, 14 Medyków Street, 40-752 Katowice, Poland.
Department of Gastroenterology with Subdivision of Internal Medicine, John Paul II Memorial Beskid Center of Oncology-Municipal Hospital in Bielsko Biala, 21 Stanisława Wyspiańskiego Street, 43-300 Bielsko-Biała, Poland.
出版信息
J Clin Med. 2021 Mar 31;10(7):1396. doi: 10.3390/jcm10071396.
BACKGROUND
Parkinson's disease (PD) is a possible risk factor for corrected QT interval (QTc) prolongation. PD patients frequently take QTc-prolonging drugs. The aim of the study was to assess the prevalence of QTc prolongation in PD and the influence of drugs and other potential risk factors on the QTc length in PD.
METHODS
101 patients with PD and a good quality ECG were included in the study. The prolonged QTc was defined as ≥450 ms for men and ≥460 ms for women. Bazett's (QTcB) and Framingham (QTcF) formulas were utilized to calculate QTc. Data about sex, age, PD duration, disease's severity, comorbidities and QTc-prolonging drugs were collected. Multiple linear regressions with backward elimination were used to assess factors influencing the QTc.
RESULTS
A long QTc was presented in 13 patients (12.9%) for QTcB and 4 patients (4%) for QTcF. Longer QTc in PD patients was associated with older age, male sex and QTc-prolonging drugs regardless of the used formula. The QTcB was also significantly affected by the heart rate (HR).
CONCLUSION
QTc prolongation is common in PD. Age, drugs and male gender are potential risk factors for QTc prolongation in PD.
背景
帕金森病（PD）是校正QT间期（QTc）延长的一个潜在风险因素。PD患者经常服用可延长QTc的药物。本研究的目的是评估PD患者中QTc延长的患病率以及药物和其他潜在风险因素对PD患者QTc长度的影响。
方法
本研究纳入了101例患有PD且心电图质量良好的患者。QTc延长定义为男性≥450毫秒，女性≥460毫秒。使用Bazett公式（QTcB）和弗雷明汉公式（QTcF）计算QTc。收集了有关性别、年龄、PD病程、疾病严重程度、合并症和可延长QTc的药物的数据。采用逐步回归的多元线性回归分析来评估影响QTc的因素。
结果
根据QTcB，13例患者（12.9%）出现QTc延长；根据QTcF，4例患者（4%）出现QTc延长。无论使用何种公式，PD患者较长的QTc都与年龄较大、男性以及可延长QTc的药物有关。QTcB还受到心率（HR）的显著影响。
结论
QTc延长在PD中很常见。年龄、药物和男性性别是PD患者QTc延长的潜在风险因素。
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