Department of Gastroenterology and Hepatology, Erasmus MC-University Medical Center Rotterdam, 3015 CN Rotterdam, The Netherlands.
Int J Mol Sci. 2021 Mar 5;22(5):2623. doi: 10.3390/ijms22052623.
The liver is one of the most important organs, playing critical roles in maintaining biochemical homeostasis. Accordingly, disease of the liver is often debilitating and responsible for untold human misery. As biochemical nexus, with kinases being master regulators of cellular biochemistry, targeting kinase enzymes is an obvious avenue for treating liver disease. Development of such therapy, however, is hampered by the technical difficulty of obtaining comprehensive insight into hepatic kinase activity, a problem further compounded by the often unique aspects of hepatic kinase activities, which makes extrapolations from other systems difficult. This consideration prompted us to review the current state of the art with respect to kinome profiling approaches towards the hepatic kinome. We observe that currently four different approaches are available, all showing significant promise. Hence we postulate that insight into the hepatic kinome will quickly increase, leading to rational kinase-targeted therapy for different liver diseases.
肝脏是最重要的器官之一，在维持生化内稳态方面起着关键作用。因此，肝脏疾病常常使人虚弱，并导致无法言喻的人类痛苦。作为生化枢纽，激酶是细胞生物化学的主要调节剂，靶向激酶酶是治疗肝脏疾病的明显途径。然而，这种治疗方法的发展受到获得全面了解肝脏激酶活性的技术难度的阻碍，而肝脏激酶活性的独特方面进一步加剧了这个问题，使得从其他系统推断变得困难。考虑到这一点，我们回顾了目前在肝脏激酶组学方面的技术现状。我们观察到，目前有四种不同的方法可用，所有这些方法都显示出了很大的前景。因此，我们推测对肝脏激酶组的了解将迅速增加，从而为不同的肝脏疾病提供合理的激酶靶向治疗。
