波兰心房颤动（POL - AF）注册研究中的有症状和无症状患者
Symptomatic and Asymptomatic Patients in the Polish Atrial Fibrillation (POL-AF) Registry.
作者信息
Kiliszek Marek, Uziębło-Życzkowska Beata, Gorczyca Iwona, Maciorowska Małgorzata, Jelonek Olga, Wożakowska-Kapłon Beata, Wójcik Maciej, Błaszczyk Robert, Gawałko Monika, Kapłon-Cieślicka Agnieszka, Tokarek Tomasz, Rajtar-Salwa Renata, Bil Jacek, Wojewódzki Michał, Szpotowicz Anna, Krzciuk Małgorzata, Bednarski Janusz, Bakuła-Ostalska Elwira, Tomaszuk-Kazberuk Anna, Szyszkowska Anna, Wełnicki Marcin, Mamcarz Artur, Krzesiński Paweł
机构信息
Department of Cardiology and Internal Diseases, Military Institute of Medicine, 04-141 Warsaw, Poland.
1st Clinic of Cardiology and Electrotherapy, Swietokrzyskie Cardiology Centre, Collegium Medicum, The Jan Kochanowski University, 25-369 Kielce, Poland.
出版信息
J Clin Med. 2021 Mar 5;10(5):1091. doi: 10.3390/jcm10051091.
BACKGROUND
Atrial fibrillation (AF) can cause severe symptoms, but it is frequently asymptomatic. We aimed to compare the clinical features of patients with asymptomatic and symptomatic AF.
METHODS
A prospective, observational, multicenter study was performed (the Polish Atrial Fibrillation (POL-AF) registry). Consecutive hospitalized AF patients over 18 years of age were enrolled at ten centers. The data were collected for two weeks during each month of 2019.
RESULTS
A total of 2785 patients were analyzed, of whom 1360 were asymptomatic (48.8%). Asymptomatic patients were more frequently observed to have coronary artery disease (57.5% vs. 49.1%, < 0.0001), heart failure with preserved ejection fraction (39.8% vs. 26.5%, < 0.0001), a previous thromboembolic event (18.2% vs. 13.1%, = 0.0002), and paroxysmal AF (52.3% vs. 45.2%, = 0.0002). In multivariate analysis, history of electrical cardioversion, paroxysmal AF, heart failure, coronary artery disease, previous thromboembolic event, and higher left ventricular ejection fraction were predictors of a lack of AF symptoms. First-diagnosed AF was a predictor of AF symptoms.
CONCLUSIONS
In comparison to symptomatic patients, more of those hospitalized with asymptomatic AF had been previously diagnosed with this arrhythmia and other cardiovascular diseases. However, they presented with better left ventricular function and were more frequently treated with cardiovascular medicines.
背景
心房颤动（AF）可导致严重症状，但通常无症状。我们旨在比较无症状和有症状AF患者的临床特征。
方法
进行了一项前瞻性、观察性、多中心研究（波兰心房颤动（POL-AF）注册研究）。在10个中心纳入了18岁以上连续住院的AF患者。在2019年的每个月中收集两周的数据。
结果
共分析了2785例患者，其中1360例无症状（48.8%）。无症状患者更常被观察到患有冠状动脉疾病（57.5%对49.1%，<0.0001）、射血分数保留的心力衰竭（39.8%对26.5%，<0.0001）、既往血栓栓塞事件（18.2%对13.1%，=0.0002）和阵发性AF（52.3%对45.2%，=0.0002）。在多变量分析中，电复律史、阵发性AF、心力衰竭、冠状动脉疾病、既往血栓栓塞事件和较高的左心室射血分数是AF无症状的预测因素。首次诊断的AF是AF症状的预测因素。
结论
与有症状患者相比，无症状AF住院患者中更多人此前已被诊断患有这种心律失常和其他心血管疾病。然而，他们的左心室功能较好，且更常接受心血管药物治疗。
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