Angiotensin receptor mediated regulation of transport in the rat proximal tubule.
作者信息
Chan Y L, Chatsudthipong V, Wang T
机构信息
Department of Physiology and Biophysics, University of Illinois College of Medicine, Chicago 60612.
出版信息
Prog Clin Biol Res. 1988;258:149-60.
PMID:3380820
Abstract
The intracellular mechanism of Ang II action, as supported by the present data, may be summarized by the following: Ang II interacts with its receptors, leading to an increase in cytosolic Ca+2 by mobilization of Ca+2 from intracellular pools. This rise in cytosolic Ca+2 initiates the activation of calmodulin-regulated enzymes. This then leads to inhibition of both JV and JHCO3-.
摘要
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