Eid M M, Hassan R A, Kadry A M
Chemistry Department, Faculty of Science, Cairo University, Giza.
Pharmazie. 1988 Mar;43(3):166-7. doi: 10.1002/chin.198840193.
6-Substituted benzyl-3-thioxo-1,2,4-triazin-5-ones 5a-e and the 4-amino derivatives 12c, e were prepared and converted into their corresponding 3-methylthio derivatives 6a-e and 13c, e, respectively of compounds 6a-e with primary and secondary amines gave the corresponding 3-amino-1,2,4-triazin-5-ones 7a-i and 8a, b. Cyclocondensation of compounds 6a-e and 13c, e with anthranilic acid was proved to give the corresponding triazino [3,2-b] quinazolindiones 9a-e and the 1-amino derivatives 11a, b.
制备了6-取代苄基-3-硫代-1,2,4-三嗪-5-酮5a - e和4-氨基衍生物12c、e，并分别将它们转化为相应的3-甲硫基衍生物6a - e和13c、e。化合物6a - e与伯胺和仲胺反应得到相应的3-氨基-1,2,4-三嗪-5-酮7a - i和8a、b。事实证明，化合物6a - e和13c、e与邻氨基苯甲酸进行环缩合反应可得到相应的三嗪并[3,2 - b]喹唑啉二酮9a - e和1-氨基衍生物11a、b。
