[3-氰基-6-甲基-5-(吡啶-4-基)-1,2-二氢吡啶-2-酮（米力农）的晶体变体]
[Crystal modifications of 3-cyan-6-methyl-5-(pyrid-4-yl)-1,2-dihydropyrid-2-one (milrinone)].
作者信息
Klauschenz E, Hagen V, Gentsch B, Niedrich H, Dathe M, Reck G, Jänsch H J
机构信息
Akademie der Wissenschaften der DDR, Institut für Wirkstofforschung, Berlin.
出版信息
Pharmazie. 1988 Mar;43(3):167-9.
The preparation and characterisation of crystalline alpha-, beta- and gamma modifications of 3-cyan-6-methyl-5-(4-pyrid-4-yl)-1,2-dihydropyrid-2-on e are described. The thermic transformation of alpha- and beta-modification into gamma-modification was proved by thermogravimetric analysis (t.g.a.), differential scanning calorimetry (d.s.c.), IR and powder diffraction pattern. In dissolution behaviour no significant differences were found between the modifications.
描述了3-氰基-6-甲基-5-(4-吡啶-4-基)-1,2-二氢吡啶-2-酮的结晶α-、β-和γ-变体的制备及表征。通过热重分析（t.g.a.）、差示扫描量热法（d.s.c.）、红外光谱和粉末衍射图谱证明了α-和β-变体向γ-变体的热转化。在溶解行为方面，各变体之间未发现显著差异。
Zotero 插件