14C-安巴腙在大鼠体内的药代动力学
Pharmacokinetics of 14C-ambazone in rats.
作者信息
Kühnel H J, Amlacher R, Kramarczyk K, Schulze W
机构信息
Academy of Sciences of the GDR, Central Institute of Microbiology and Experimental Therapy, Jena.
出版信息
Pharmazie. 1988 Mar;43(3):197-9.
In rats, the pharmacokinetics of 14C-ambazone after i.v. and oral administration was studied. The results demonstrate that the compound is incompletely absorbed from the gastrointestinal tract, penetrates rapidly and to a high degree into various tissues and is preferentially eliminated via the kidneys. After i.v. administration of 50 mg/kg b.m. disposition half-life in whole blood is about 6-7 h. The extent of absorption from the gastrointestinal tract is about 40%.
在大鼠中，研究了静脉注射和口服14C-安巴腙后的药代动力学。结果表明，该化合物从胃肠道吸收不完全，能迅速且高度渗透到各种组织中，并优先通过肾脏消除。静脉注射50mg/kg体重后，全血中的处置半衰期约为6-7小时。胃肠道的吸收程度约为40%。
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