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PACAP-38 在人类和猪的急性 ST 段抬高型心肌梗死中的作用：一项转化研究。

PACAP-38 in Acute ST-Segment Elevation Myocardial Infarction in Humans and Pigs: A Translational Study.

机构信息

Heart Institute, Medical School, University of Pecs, 7624 Pecs, Hungary.

Department of Anatomy, MTA-PTE PACAP Research Team, Centre for Neuroscience, Medical School, University of Pecs, 7624 Pecs, Hungary.

出版信息

Int J Mol Sci. 2021 Mar 12;22(6):2883. doi: 10.3390/ijms22062883.

DOI:10.3390/ijms22062883
PMID:33809145
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8002092/
Abstract

Acute myocardial infarction (MI) is one of the most common causes of death worldwide. Pituitary adenylate cyclase activating polypeptide (PACAP) is a cardioprotective neuropeptide expressing its receptors in the cardiovascular system. The aim of our study was to examine tissue PACAP-38 in a translational porcine MI model and plasma PACAP-38 levels in patients with ST-segment elevation myocardial infarction (STEMI). Significantly lower PACAP-38 levels were detected in the non-ischemic region of the left ventricle (LV) in MI heart compared to the ischemic region of MI-LV and also to the Sham-operated LV in porcine MI model. In STEMI patients, plasma PACAP-38 level was significantly higher before percutaneous coronary intervention (PCI) compared to controls, and decreased after PCI. Significant negative correlation was found between plasma PACAP-38 and troponin levels. Furthermore, a significant effect was revealed between plasma PACAP-38, hypertension and HbA1c levels. This was the first study showing significant changes in cardiac tissue PACAP levels in a porcine MI model and plasma PACAP levels in STEMI patients. These results suggest that PACAP, due to its cardioprotective effects, may play a regulatory role in MI and could be a potential biomarker or drug target in MI.

摘要

急性心肌梗死（MI）是全球最常见的死亡原因之一。垂体腺苷酸环化酶激活肽（PACAP）是一种心脏保护性神经肽，在心血管系统中表达其受体。我们的研究目的是在转化猪 MI 模型中检查组织 PACAP-38，并在 ST 段抬高型心肌梗死（STEMI）患者中检查血浆 PACAP-38 水平。与 MI-LV 的缺血区和猪 MI 模型中的 Sham 操作 LV 相比，MI 心脏的左心室（LV）非缺血区中检测到的 PACAP-38 水平明显降低。在 STEMI 患者中，与对照组相比，经皮冠状动脉介入治疗（PCI）前的血浆 PACAP-38 水平明显升高，PCI 后降低。发现血浆 PACAP-38 与肌钙蛋白水平之间存在显著负相关。此外，还揭示了血浆 PACAP-38、高血压和 HbA1c 水平之间存在显著影响。这是第一项在猪 MI 模型中显示心脏组织 PACAP 水平和 STEMI 患者血浆 PACAP 水平发生显著变化的研究。这些结果表明，由于其心脏保护作用，PACAP 可能在 MI 中发挥调节作用，并且可能是 MI 的潜在生物标志物或药物靶标。

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