Lower E E, Smith J T, Martelo O J, Baughman R P
Department of Internal Medicine, University of Cincinnati Medical Center, OH.
Sarcoidosis. 1988 Mar;5(1):51-5.
Anemia and leukopenia have been reported in sarcoidosis. In order to characterize the prevalence and association with disease activity, 75 patients with active pulmonary sarcoidosis were studied. One or more hematologic abnormalities were identified in 87% of patients studied. Anemia was present in 21 patients (28%), and bone marrow examination in 17 anemic patients revealed noncaseating granulomas in 9 patients and absent iron stores in 8 patients. The bone marrow aspirates did not show characteristics seen in other anemias of chronic disease, such as tuberculosis. In the majority of unexplained anemia cases, hemoglobin levels normalized with prednisone treatment. Forty-one of 75 patients (55%) had lymphopenia. Anemia found in patients with active sarcoidosis was associated with noncaseating granulomas in the bone marrow and an improvement with steroid therapy.
结节病患者中曾有贫血和白细胞减少症的报道。为了明确其患病率以及与疾病活动的关联，对75例活动性肺结节病患者进行了研究。在接受研究的患者中，87%被发现存在一种或多种血液学异常。21例患者（28%）出现贫血，对17例贫血患者进行的骨髓检查显示，9例患者存在非干酪样肉芽肿，8例患者铁储备缺乏。骨髓穿刺检查未显示出在其他慢性病贫血（如结核病）中所见的特征。在大多数不明原因的贫血病例中，血红蛋白水平经泼尼松治疗后恢复正常。75例患者中有41例（55%）出现淋巴细胞减少。活动性结节病患者中发现的贫血与骨髓中的非干酪样肉芽肿有关，且经类固醇治疗后有所改善。
