Department of Obstetrics and Gynecology, McGill University Health Centre, McGill University, Montreal, QC, Canada.
Int J Gynaecol Obstet. 2022 Mar;156(3):516-520. doi: 10.1002/ijgo.13694. Epub 2021 Apr 19.
To compare pregnancy rates of donor versus partner sperm in intrauterine insemination (IUI) cycles in women aged 38 years and above.
A retrospective cohort study was performed using data from 944 women aged 38-43 years old who underwent a combined 1596 IUI cycles at an academic fertility clinic in Montreal, Canada between February 2009 to April 2018.
Partner sperm was used in 1421 cycles (89.0%), and donor sperm was inseminated in 175 cycles (11.0%). Mean ages of the women were 39.8 (±1.5) and 40.2 (±1.6) years in the partner and donor insemination groups, respectively (P < 0.001). Positive serum (β human chorionic gonadotropin) pregnancy rate in the partner sperm group was 9.0% (n = 128) whereas that in the donor insemination group was 9.7% (n = 17) (P = 0.759). Clinical pregnancy rates were 5.8% (n = 83) and 8.0% (n = 14) in the respective groups (P = 0.260). There were five multiple gestation (twin) pregnancies in the cohort, three in those undergoing IUI with partner sperm and two in those undergoing IUI with donor sperm.
In women aged 38-43 years undergoing IUI with controlled ovarian stimulation, using donor sperm, compared with partner sperm, did not increase rate of pregnancy.
比较宫腔内人工授精（IUI）中 38 岁及以上女性使用供精与配偶精子的妊娠率。
采用回顾性队列研究，选取 2009 年 2 月至 2018 年 4 月在加拿大蒙特利尔一家学术生育诊所接受 IUI 治疗的 944 名年龄在 38-43 岁的女性的资料，共进行了 1596 个 IUI 周期。
1421 个周期（89.0%）使用配偶精子，175 个周期（11.0%）使用供精。配偶精子组和供精组女性的平均年龄分别为 39.8（±1.5）岁和 40.2（±1.6）岁（P＜0.001）。配偶精子组血清（β 人绒毛膜促性腺激素）阳性妊娠率为 9.0%（n=128），供精组为 9.7%（n=17）（P=0.759）。两组的临床妊娠率分别为 5.8%（n=83）和 8.0%（n=14）（P=0.260）。该队列中共有 5 例多胎妊娠（双胞胎），其中 3 例发生在接受配偶精子 IUI 的患者中，2 例发生在接受供精 IUI 的患者中。
在接受控制性卵巢刺激的 38-43 岁女性中，与配偶精子相比，使用供精并未增加妊娠率。
