细菌性脑膜炎患者脑脊液中人类肝表达抗菌肽 2 升高。
Human liver-expressed antimicrobial peptide 2 elevation in the cerebrospinal fluid in bacterial meningitis.
机构信息
Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
出版信息
Brain Behav. 2021 May;11(5):e02111. doi: 10.1002/brb3.2111. Epub 2021 Apr 3.
OBJECTIVE
To study the presence of liver-expressed antimicrobial peptide 2 (LEAP2) in human cerebrospinal fluid (CSF) and to measure its concentrations in neurological disorders.
MATERIALS & METHODS: We identified the presence of LEAP2 in human CSF by chromatographic analysis and a LEAP2-specific enzyme immunoassay. We measured LEAP2 concentrations in the CSF of 35 patients with neurological disorders.
RESULTS
CSF LEAP2 concentrations in the bacterial meningitis group (mean ± SD, 9.32 ± 3.76 ng/ml) were significantly higher (p < .05) than those in the other four groups (psychosomatic disorder, 0.56 ± 0.15 ng/ml; peripheral autoimmune disease, 1.00 ± 0.60 ng/ml; multiple sclerosis, 0.62 ± 0.30 ng/ml; aseptic meningitis, 1.59 ± 0.69 ng/ml).
CONCLUSIONS
This is the first study to identify the presence of human LEAP2 in the CSF. Levels of LEAP2 were increased in the CSF of patients with bacterial meningitis. LEAP2 may have potential as a biomarker for bacterial meningitis.
目的
研究人脑脊液中肝表达抗菌肽 2（LEAP2）的存在，并测量其在神经疾病中的浓度。
材料与方法
我们通过色谱分析和 LEAP2 特异性酶免疫测定来鉴定人脑脊液中 LEAP2 的存在。我们测量了 35 例神经疾病患者脑脊液中的 LEAP2 浓度。
结果
细菌性脑膜炎组的脑脊液 LEAP2 浓度（平均值 ± 标准差，9.32 ± 3.76 ng/ml）明显高于其他四组（心身障碍，0.56 ± 0.15 ng/ml；周围自身免疫性疾病，1.00 ± 0.60 ng/ml；多发性硬化症，0.62 ± 0.30 ng/ml；无菌性脑膜炎，1.59 ± 0.69 ng/ml）（p <.05）。
结论
这是首次在脑脊液中鉴定出人 LEAP2 的存在的研究。LEAP2 的水平在细菌性脑膜炎患者的脑脊液中增加。LEAP2 可能作为细菌性脑膜炎的生物标志物具有潜力。
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