Shimoda K, Okamura S, Omori F, Mizuno Y, Hara T, Aoki T, Akeda H, Ueda K, Niho Y
Cancer Center, Kyushu University, Fukuoka, Japan.
Acta Haematol. 1991;86(1):36-9. doi: 10.1159/000204796.
The level of granulocyte-macrophage colony-stimulating factor (GM-CSF) in the cerebrospinal fluid from 14 infants and children with meningitis and 6 patients who suffered other diseases besides meningitis was measured by our sensitive enzyme linked immunosorbent assay for GM-CSF. The minimal detection level of GM-CSF was 40 pg/ml. Six of 9 patients (67%) with aseptic meningitis had detectable GM-CSF in cerebrospinal fluid and the concentrations of GM-CSF ranged from 49 to 114 pg/ml (mean 72 pg/ml), whereas none of 5 patients with bacterial meningitis or 6 patients with other diseases besides meningitis had detectable GM-CSF levels. There was no clear correlation between the GM-CSF levels in cerebrospinal fluid and the leukocyte count in either peripheral blood or cerebrospinal fluid, or the concentration of protein or glucose in cerebrospinal fluid.
我们采用灵敏的粒细胞巨噬细胞集落刺激因子（GM-CSF）酶联免疫吸附测定法，对14例患脑膜炎的婴幼儿及儿童以及6例除脑膜炎外还患有其他疾病的患者脑脊液中的GM-CSF水平进行了检测。GM-CSF的最低检测水平为40 pg/ml。9例无菌性脑膜炎患者中有6例（67%）脑脊液中可检测到GM-CSF，GM-CSF浓度范围为49至114 pg/ml（平均72 pg/ml），而5例细菌性脑膜炎患者及6例除脑膜炎外还患有其他疾病的患者中，无一例脑脊液GM-CSF水平可被检测到。脑脊液中的GM-CSF水平与外周血或脑脊液中的白细胞计数，或脑脊液中的蛋白质或葡萄糖浓度之间均无明显相关性。
