Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon; World Health Organization (WHO) Collaborating Center for Reference and Research on Bacterial Pathogens, Beirut, Lebanon.
Department of Experimental Pathology, Immunology and Microbiology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon; Center for Infectious Diseases Research, American University of Beirut, Beirut, Lebanon; World Health Organization (WHO) Collaborating Center for Reference and Research on Bacterial Pathogens, Beirut, Lebanon.
J Glob Antimicrob Resist. 2021 Jun;25:209-221. doi: 10.1016/j.jgar.2021.02.033. Epub 2021 Apr 1.
Carbapenem resistance in Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosa is increasing worldwide, which has led the World Health Organization (WHO) to list these bacteria in the critical priority pathogens group. Infections by such pathogens pose a serious threat to hospitalised patients and are associated with clinical and economic consequences. What worsens the case is the weak pipeline of available antimicrobial agents to treat such infections and the absence of new drugs. The aim of this review was to shed light on all studies tackling carbapenem resistance in Enterobacteriaceae, A. baumannii and P. aeruginosa in the Eastern Mediterranean region, with indication for each country, description of studies timeline, prevalence of carbapenem resistance, and carbapenem resistance-encoding genes detected in these countries.
肠杆菌科、鲍曼不动杆菌和铜绿假单胞菌的碳青霉烯类耐药性在全球范围内不断增加，世界卫生组织（WHO）已将这些细菌列入关键优先病原体组。此类病原体引起的感染对住院患者构成严重威胁，并与临床和经济后果相关。更糟糕的是，可用于治疗此类感染的抗菌药物供应有限，且没有新的药物。本综述的目的是阐明在东地中海地区开展的所有关于肠杆菌科、鲍曼不动杆菌和铜绿假单胞菌碳青霉烯类耐药性的研究，包括每个国家的指示、研究时间线描述、碳青霉烯类耐药性的流行情况以及这些国家检测到的碳青霉烯类耐药基因。
