约旦慢性阻塞性肺疾病患者口服和静脉注射后血浆茶碱水平的个体间变异性。

Intersubject variability in plasma theophylline levels after oral and intravenous administration in Jordanian patients with chronic obstructive pulmonary disease.

作者信息

Samara N, Sliman N, Sai'd S, Awidi A, Al-Turk W, Othman S, Khalaf R, Shaheen O

机构信息

Faculty of Medicine, University of Jordan, Amman.

出版信息

Ther Drug Monit. 1988;10(2):144-6. doi: 10.1097/00007691-198802000-00003.

DOI:10.1097/00007691-198802000-00003

PMID:3381229

Abstract

Plasma theophylline concentrations were determined in 151 Jordanian patients with chronic obstructive pulmonary disease. Mean plasma levels after oral administration were below the therapeutic range and significantly lower than after intravenous administration. Plasma levels in patients with congestive heart failure (CHF) were higher than in patients with no CHF. Trough plasma theophylline concentrations after intravenous administration in patients less than 18 years of age were significantly lower than in those aged 18-60 years. The overall results are in agreement with observations made in other ethnic groups.

摘要

对151名患有慢性阻塞性肺疾病的约旦患者测定了血浆茶碱浓度。口服给药后的平均血浆水平低于治疗范围，且显著低于静脉给药后的水平。充血性心力衰竭（CHF）患者的血浆水平高于无CHF的患者。18岁以下患者静脉给药后的血浆茶碱谷浓度显著低于18 - 60岁的患者。总体结果与在其他种族群体中观察到的结果一致。