Li Gao, Huang Xiu-Juan, Niu Tong, Wei Chi, Cheng Ming-Xia, Han Cai-Juan, Sun Yan-Qing
Department of Hematology, Gansu Provincial Hospital; Lanzhou 730000, Gansu Province, China.
Clinical Medicine School, Gansu University of Chinese Medicine,Lanzhou 730000, Gansu Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Apr;29(2):553-556. doi: 10.19746/j.cnki.issn.1009-2137.2021.02.039.
To investigate the expression of CD56 in multiple myeloma (MM) cells and its relationship between extramedullary disease and extramedullary relapse.
Clinical data of 99 patients with MM treated in our hospital from January 2015 to December 2019 was retrospectively analyzed. The patients were divided into positive group and negative group according to the expression of CD56. The relationship between CD56 and multiple myeloma extramedullary disease, extramedullary relapse was analyzed.
Among 99 newly diagnosed patients with MM, the positive rate of CD56 was 65%, and the incidence of extramedullary disease of patients in the CD56 positive group was lower than that in the CD56 negative group (17.19% vs 48.57%) (P<0.01). Meanwhile, the incidence of extramedullary relapse of patients in the CD56 positive group was lower than that in the CD56 negative group (1.56% vs 34.29%) (P<0.01).
CD56 is highly expressed in MM, and its low expression is associated with the occurrence of extramedullary disease and extramedullary relapse, which suggests that CD56 may be an important indicator for predicting the occurrence of extramedullary disease and extramedullary relapse.
探讨CD56在多发性骨髓瘤（MM）细胞中的表达及其与髓外疾病和髓外复发的关系。
回顾性分析2015年1月至2019年12月在我院治疗的99例MM患者的临床资料。根据CD56表达情况将患者分为阳性组和阴性组。分析CD56与多发性骨髓瘤髓外疾病、髓外复发的关系。
99例新诊断的MM患者中，CD56阳性率为65%，CD56阳性组患者髓外疾病发生率低于CD56阴性组（17.19%对48.57%）（P<0.01）。同时，CD56阳性组患者髓外复发率低于CD56阴性组（1.56%对34.29%）（P<0.01）。
CD56在MM中高表达，其低表达与髓外疾病和髓外复发的发生有关，提示CD56可能是预测髓外疾病和髓外复发发生的重要指标。
