三酰甘油葡萄糖指数对慢性心力衰竭合并 2 型糖尿病患者预后的价值：一项回顾性队列研究。
The prognostic value of the triglyceride glucose index in patients with chronic heart failure and type 2 diabetes: A retrospective cohort study.
机构信息
Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, China.
Department of Ambulatory Surgery, Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen, China.
出版信息
Diabetes Res Clin Pract. 2021 Jul;177:108786. doi: 10.1016/j.diabres.2021.108786. Epub 2021 Apr 1.
AIMS
The triglyceride glucose (TyG) index is a marker of insulin resistance. However, the prognostic value thereof in patients with chronic heart failure (CHF) and type 2 diabetes remains unclear.
METHODS
This study included patients diagnosed with CHF and type 2 diabetes in Fuwai Hospital of Chinese Academy of Medical Sciences, Shenzhen, from January 2017 to July 2019. The primary endpoint was cardiovascular death or rehospitalization for heart failure.
RESULTS
The study included 546 patients with CHF and type 2 diabetes. We divided the patients into three groups (T1 [TyG index < 8.55], T2 [TyG index ≥ 8.55 and < 9.06], and T3 [TyG index ≥ 9.06]) according to the TyG index level. The incidence of the primary outcome in the T3 group was significantly higher than that in the T1 group. There was no significant difference between the T1 and T2 groups. The trend test revealed a positive correlation between the TyG index and the incidence of the primary outcome (P = 0.001).
CONCLUSIONS
There is a positive correlation between the TyG index and the prognosis of patients with CHF and type 2 diabetes.
目的
三酰甘油葡萄糖（TyG）指数是胰岛素抵抗的标志物。然而，其在慢性心力衰竭（CHF）和 2 型糖尿病患者中的预后价值尚不清楚。
方法
本研究纳入了 2017 年 1 月至 2019 年 7 月在中国医学科学院阜外医院深圳医院诊断为 CHF 和 2 型糖尿病的患者。主要终点为心血管死亡或心力衰竭再入院。
结果
本研究纳入了 546 例 CHF 和 2 型糖尿病患者。我们根据 TyG 指数水平将患者分为三组（T1 [TyG 指数<8.55]、T2 [TyG 指数≥8.55 且<9.06]和 T3 [TyG 指数≥9.06]）。T3 组的主要结局发生率明显高于 T1 组。T1 组和 T2 组之间无显著差异。趋势检验显示 TyG 指数与主要结局发生率之间存在正相关（P=0.001）。
结论
TyG 指数与 CHF 和 2 型糖尿病患者的预后呈正相关。
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