肿瘤大小和 N2 淋巴结转移是完全切除的中央型原发性肺癌患者早期复发的重要危险因素。
Tumor Size and N2 Lymph Node Metastasis Are Significant Risk Factors for Early Recurrence in Completely Resected Centrally Located Primary Lung Cancer Patients.
机构信息
Department of Thoracic Surgery, Osaka City University Hospital, Osaka, Japan
Department of Thoracic Surgery, Osaka City University Hospital, Osaka, Japan.
出版信息
Anticancer Res. 2021 Apr;41(4):2165-2169. doi: 10.21873/anticanres.14989.
BACKGROUND/AIM: In centrally-located lung cancer treatment, it is difficult to attain a sufficient resection margin. It is important to investigate recurrent styles in centrally-located lung cancer patients.
PATIENTS AND METHODS
Primary lung cancer located at the hilar area that requires pneumonectomy or sleeve lobectomy is defined as centrally-located lung cancer. Early recurrence was defined as that within 1 year after surgery.
RESULTS
This study included 43 centrally-located lung cancer patients. Ten patients underwent pneumonectomy and 33 underwent sleeve lobectomy. Eleven patients experienced early recurrence. Non-squamous cell carcinoma (p=0.012), tumor size>64 mm (p<0.001) and pathological N2 (p=0.012) were significant predictors for early recurrence by univariate analysis. Also, tumor size >64 mm (p=0.006) and pathological N2 (p=0.019) were independent predictors by multivariate analysis.
CONCLUSION
Non-squamous cell carcinoma, tumor size and pathological N2 were significant predictors of early recurrence in centrally-located lung cancer. The type of surgical procedure did not affect recurrence development.
背景/目的：在中央型肺癌的治疗中，很难达到足够的切缘。因此，研究中央型肺癌患者的复发方式非常重要。
患者与方法
本研究将需要行全肺切除术或袖状肺叶切除术的肺门区原发性肺癌定义为中央型肺癌。早期复发定义为术后 1 年内复发。
结果
本研究共纳入 43 例中央型肺癌患者，其中 10 例行全肺切除术，33 例行袖状肺叶切除术。11 例患者发生早期复发。单因素分析显示，非鳞癌（p=0.012）、肿瘤直径>64mm（p<0.001）和病理 N2（p=0.012）是早期复发的显著预测因素。多因素分析显示，肿瘤直径>64mm（p=0.006）和病理 N2（p=0.019）是独立的预测因素。
结论
非鳞癌、肿瘤大小和病理 N2 是中央型肺癌早期复发的显著预测因素。手术方式并不影响复发的发生。
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