Shimadzu Scientific Instruments, Inc., Columbia, MD, USA.
Eurofins Lancaster Laboratories, Inc., Lancaster, PA, USA.
J Sep Sci. 2021 Jun;44(11):2234-2249. doi: 10.1002/jssc.202000858. Epub 2021 Apr 22.
Per- and polyfluorinated alkyl substances are large class of man-made compounds known in the media as "forever chemicals". In 2015, ASTM International published ASTM D7979, for the analysis of per- and polyfluorinated alkyl substances in non-potable water samples. This method extracts the substances by co-solvation with methanol and measures targeted compounds using liquid chromatography-tandem mass spectrometry. ASTM D7979 is a performance-based method that analyzes 31 compounds plus 14 isotopically labeled surrogates. The minimum reporting limit is approximately 10 ng/L with an analytical range of 10-200 ng/L for most compounds. Expected recovery of surrogates and spiked matrices is 70-130%. Samples containing high suspended solids can be analyzed with minimal interferences and potential loss of analyte. The method is consistent with ASTM and EPA's sustainable development goals by using reduced volumes of sample, solvent, and minimizing hazardous solvents and sample preparation materials while maintaining data quality and detection limits that are suitable for the intended use. This paper covers the rationale, outlines some of the challenges associated with analysis of per- and polyfluorinated alkyl substances, and describes the steps taken by the ASTM Committee D19 task group to develop, optimize, and validate this method.
全氟和多氟烷基物质是一大类人工合成化合物，在媒体中被称为“永久性化学物质”。2015 年，ASTM 国际发布了 ASTM D7979，用于分析非饮用水样中的全氟和多氟烷基物质。该方法通过甲醇共溶剂萃取物质，并使用液相色谱-串联质谱法测量目标化合物。ASTM D7979 是一种基于性能的方法，分析 31 种化合物加 14 种同位素标记的替代物。最低报告限约为 10ng/L，大多数化合物的分析范围为 10-200ng/L。替代物和加标基质的预期回收率为 70-130%。含有高悬浮固体的样品可以进行分析，干扰最小，分析物可能损失最小。该方法通过减少样品、溶剂的用量，尽量减少危险溶剂和样品制备材料的使用，同时保持数据质量和检测限，符合 ASTM 和 EPA 的可持续发展目标，这些目标适用于预期用途。本文介绍了该方法的基本原理，概述了分析全氟和多氟烷基物质所面临的一些挑战，并描述了 ASTM 委员会 D19 工作组为开发、优化和验证该方法所采取的步骤。
