没食子醇和高丝氨酸：从真菌中分离出的恶性疟原虫二氢乳清酸脱氢酶抑制剂。
Gentisyl alcohol and homogentisic acid: Plasmodium falciparum dihydroorotate dehydrogenase inhibitors isolated from fungi.
机构信息
Graduate School of Infection Control Sciences, Kitasato University.
Laboratory for Biotechnology, Agency for the Assessment and Application of Technology (BPPT).
出版信息
J Gen Appl Microbiol. 2021 Jul 31;67(3):114-117. doi: 10.2323/jgam.2020.08.004. Epub 2021 Apr 2.
Two Indonesian fungi Aspergillus assiutensis BioMCC-f.T.7495 and Penicillium pedernalense BioMCC-f.T.5350 along with a Japanese fungus Hypomyces pseudocorticiicola FKI-9008 have been found to produce gentisyl alcohol (1), which inhibits Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) with an IC value of 3.4 μM. Another Indonesian fungus, Penicillium citrinum BioMCC-f.T.6730, produced an analog of 1, homogentisic acid (4), which also inhibits PfDHODH with an IC value of 47.6 μM.
已发现两种印度尼西亚真菌—— Aspergillus assiutensis BioMCC-f.T.7495 和 Penicillium pedernalense BioMCC-f.T.5350，以及一种日本真菌 Hypomyces pseudocorticiicola FKI-9008，能够产生 gentisyl alcohol（1），其对 Plasmodium falciparum dihydroorotate dehydrogenase（PfDHODH）的抑制作用的 IC 值为 3.4 μM。另一种印度尼西亚真菌 Penicillium citrinum BioMCC-f.T.6730 则产生了 1 的类似物 homogentisic acid（4），其对 PfDHODH 的抑制作用的 IC 值为 47.6 μM。
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