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骨骼未成熟患者肿瘤切除术后的骨骺挽救重建及相关并发症

Epiphysis Salvage Reconstruction and Associated Complications Following Tumor Resections in Skeletally Immature Patients.

作者信息

Kapukaya Rana, Karaali Evren, Çiloğlu Osman, Oğur Hasan Ulaş, Baydar Mehmet, Öztürk Kahraman

机构信息

Department of Plastic, Reconstructive and Aesthetic Surgery, University of Health Science Adana City Training and Research Hospital, Adana, Turkey.

Department of Orthopedics and Traumatology, University of Health Science Adana City Training and Research Hospital, Mithat Özhan Bulvarı Kışla Mah. No:1 Yüreğir, Adana, Turkey.

出版信息

Indian J Surg Oncol. 2021 Mar;12(1):164-171. doi: 10.1007/s13193-020-01275-4. Epub 2021 Jan 4.

Abstract

The purpose of this study was to discuss the epiphysis salvage reconstruction procedure outcomes and complications in skeletally immature patients. The study included 12 patients with pediatric malignant tumors (osteosarcoma, Ewing's sarcoma) located close to the epiphysis, who underwent epiphyseal-preservation surgery with vascularized fibula in the plastic surgery and orthopedics and traumatology clinic between January 2008 and November 2018. The study was designed retrospectively. Neoadjuvant and adjuvant chemotherapy was administered to all patients. None of the patients received radiotherapy. Functional evaluation was assessed using the Musculoskeletal Tumor Society (MSTS) scoring system. The patients were followed up for a mean period of 51 (21‑115) months. The mean age of patients was 10.4 (range, 5 to 15) years. Union times in the target region (epiphyseal region) and diaphyseal region were reported separately. Accordingly, the mean total union time in the target region of all patients was 7.9 months (5‑11), and the mean total union time in the diaphyseal region was 6.5 months (5‑9). According to the MSTS grading system, the mean score of the patients was 27.50 (range, 21‑30). The mean operative time was 480 (390‑540) min, the mean intraoperative blood loss was 790 (580‑1100) cc, and the mean length of hospital stay was 6 (4‑17) days. Six patients had shortness, 5 patients had delayed union, 3 patients had angular deformity, and 2 patients had infection. Epiphyseal-preservation surgery may be an alternative to other techniques used for malignant tumors located close to the growth line in skeletally immature patients. Despite the fact that this technique has plenty of complications, many of them can be successfully treated with secondary operations without leaving sequelae.

摘要

本研究的目的是探讨骨骼未成熟患者的骨骺挽救重建手术的结果及并发症。该研究纳入了12例骨骺附近患有小儿恶性肿瘤(骨肉瘤、尤因肉瘤)的患者,他们于2008年1月至2018年11月期间在整形外科、骨科及创伤科门诊接受了带血管腓骨骨骺保留手术。本研究为回顾性设计。所有患者均接受了新辅助化疗和辅助化疗。所有患者均未接受放疗。使用肌肉骨骼肿瘤学会(MSTS)评分系统进行功能评估。患者平均随访51(21 - 115)个月。患者的平均年龄为10.4(范围5至15)岁。分别报告了目标区域(骨骺区域)和骨干区域的愈合时间。据此,所有患者目标区域的平均总愈合时间为7.9个月(5 - 11),骨干区域的平均总愈合时间为6.5个月(5 - 9)。根据MSTS分级系统,患者的平均评分为27.50(范围21 - 30)。平均手术时间为480(390 - 540)分钟,平均术中失血量为790(580 - 1100)毫升,平均住院时间为6(4 - 17)天。6例患者出现肢体短缩,5例患者出现延迟愈合,3例患者出现角状畸形,2例患者出现感染。骨骺保留手术可能是骨骼未成熟患者中用于治疗生长线附近恶性肿瘤的其他技术的一种替代方法。尽管该技术有许多并发症,但其中许多可以通过二次手术成功治疗且不留后遗症。

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