Nguyen B L, Hatier R, Jeanvoine G, Roux M, Grignon G, Pasqualini J R
C.N.R.S. Steroid Hormone Research Unit, Foundation for Hormone Research, Paris, France.
Acta Endocrinol (Copenh). 1988 Feb;117(2):249-59. doi: 10.1530/acta.0.1170249.
The effect provoked by estradiol after administration to pregnant rats (1 mg per day) was studied in fetal and newborn uteri and ovary. Estrogen receptors are found in the fetuses of non-treated animals. Their number (in fmol/mg DNA, +/- SD) in the fetal uterus (total sites, cytosol + nuclei) was at the age of 18 days: 63 +/- 15; at 20 days 101 +/- 13; and in the 24-h-old newborn; 415 +/- 120. The respective values in the ovary were: 105 +/- 25; 520 +/- 60 and 410 +/- 190. Estradiol stimulated significantly the progesterone receptor in the fetal uterus at 20 days old. The progesterone receptor (in fmol/mg DNA, +/- SD) which was 97 +/- 17 in the non-treated animals, increased to 790 +/- 90 in the E2-primed animals. Newborns, 24-h-old, had no detectable progesterone receptor, but in the E2-treated animals the value increased to 1210 +/- 120. In the fetal ovary of non-treated animals, progesterone receptor at the age of 18 days is: 90 +/- 19; at 20 days 132 +/- 47, and in the newborns 260 +/- 67; in the E2-treated animals, the values are respectively 330 +/- 49; 865 +/- 78 and 1280 +/- 307. In the fetal uteri of E2-treated animals, histological and ultrastructural studies showed an increase in the size of the uterine horn, the height of the epithelial cells, and stromal cell differentiation. It is suggested that, as was extensively demonstrated in the fetal compartment of the guinea-pig, the machinery for estrogen responses operates also during fetal development of the rat.
研究了给怀孕大鼠每日注射1毫克雌二醇后对胎儿及新生大鼠子宫和卵巢的影响。在未处理动物的胎儿中发现了雌激素受体。其数量（以fmol/mg DNA计，±标准差）在胎儿子宫（总位点，胞质溶胶+细胞核）中，18日龄时为：63±15；20日龄时为101±13；在出生24小时的新生儿中为415±120。卵巢中的相应数值分别为：105±25；520±60和410±190。雌二醇显著刺激了20日龄胎儿子宫中的孕酮受体。未处理动物中孕酮受体（以fmol/mg DNA计，±标准差）为97±17，在经E2预处理的动物中增加到790±90。出生24小时的新生儿未检测到孕酮受体，但在经E2处理的动物中，该数值增加到1210±120。在未处理动物的胎儿卵巢中，18日龄时孕酮受体为：90±19；20日龄时为132±47，在新生儿中为260±67；在经E2处理的动物中，相应数值分别为330±49；865±78和1280±307。在经E2处理的动物的胎儿子宫中，组织学和超微结构研究显示子宫角大小增加、上皮细胞高度增加以及基质细胞分化。有人提出，正如在豚鼠胎儿部分广泛证明的那样，雌激素反应机制在大鼠胎儿发育过程中也起作用。
