Hu Kang, Zheng Qing-Kang, Ma Rui-Jie, Ma Chao, Sun Zhi-Gang, Zhang Nan
School of Clinical Medicine, Weifang Medical University, Weifang, China.
Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Cell Dev Biol. 2021 Mar 18;9:661731. doi: 10.3389/fcell.2021.661731. eCollection 2021.
Krüppel-like factor 6 (KLF6) is one of the most studied members of the specificity protein/Krüppel-like factor (SP/KLF) transcription factor family. It has a typical zinc finger structure and plays a pivotal role in regulating the biological processes of cells. Recently, it has been considered to play a role in combatting cancer. Krüppel-like factor 6 splice variant 1 (KLF6-SV1), being one of the alternative KLF6 splicing isoforms, participates in tumor occurrence and development and has the potential to become a new target for molecular targeted therapy, although its action mechanism remains to be determined. The purpose of this article is to provide a comprehensive and systematic review of the important role of KLF6-SV1 in human malignant tumors to provide novel insights for oncotherapy.
Krüppel样因子6（KLF6）是特异性蛋白/Krüppel样因子（SP/KLF）转录因子家族中研究最多的成员之一。它具有典型的锌指结构，在调节细胞生物学过程中起关键作用。最近，它被认为在抗癌方面发挥作用。Krüppel样因子6剪接变体1（KLF6-SV1）作为KLF6的可变剪接异构体之一，参与肿瘤的发生和发展，尽管其作用机制尚待确定，但它有潜力成为分子靶向治疗的新靶点。本文旨在对KLF6-SV1在人类恶性肿瘤中的重要作用进行全面系统综述，为肿瘤治疗提供新的见解。
