• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

五种 microRNAs（rs2910164、rs11614913、rs3746444、rs11134527 和 rs531564）的基因变异与宫颈癌风险的关联：荟萃分析。

The Association between Five Genetic Variants in MicroRNAs (rs2910164, rs11614913, rs3746444, rs11134527, and rs531564) and Cervical Cancer Risk: A Meta-Analysis.

机构信息

Department of Obstetrics and Gynecology, Xuanwu Hospital, Capital Medical University, Beijing, China.

出版信息

Biomed Res Int. 2021 Mar 15;2021:9180874. doi: 10.1155/2021/9180874. eCollection 2021.

DOI:10.1155/2021/9180874
PMID:33816633
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7987420/
Abstract

The objective of this study was to conduct a meta-analysis to systematically summarize and investigate the association of miRNA-124 rs531564, miRNA-218 rs11134527, miRNA-146a rs2910164, miRNA-196a2 rs11614913, and miRNA-499 rs3746444 polymorphisms with cervical cancer. A systematic review was performed to identify relevant studies using Embase and PubMed databases. A chi-square-based -test combined with the inconsistency index ( ) was used to check the heterogeneity between studies. A total of six case-control studies on rs2910164 and rs11614913, 4 studies on rs3746444 and rs11134527, and three studies on rs531564 were included. No evidence of association was found between miR-146a rs2910164, miR-196a2 rs11614913, miRNA-499 rs3746444, and miR-218 rs11134527 polymorphisms and cervical cancer risk in all the genetic models. The miR-124 rs531564 polymorphism was associated with a statistically increased risk of cervical cancer in a homozygote model (CC vs. GG: OR = 2.87, 95% CI: 1.40-5.91, = 0.887), dominant model (GC/CC vs. GG: OR = 1.38, 95% CI: 1.07-1.80, = 0.409), and recessive model (CC vs. GC/GG: OR = 2.26, 95% CI: 1.58-3.23, = 0.979). However, this finding should be interpreted with caution for limited samples and heterogeneity. Large-scale and well-designed studies are needed to validate our result.

摘要

本研究旨在进行荟萃分析，系统总结和探讨 miRNA-124 rs531564、miRNA-218 rs11134527、miRNA-146a rs2910164、miRNA-196a2 rs11614913 和 miRNA-499 rs3746444 多态性与宫颈癌的相关性。通过 Embase 和 PubMed 数据库进行系统综述以确定相关研究。使用基于卡方的检验和不一致指数（ ）来检验研究之间的异质性。共纳入了 rs2910164 和 rs11614913 的 6 项病例对照研究、rs3746444 和 rs11134527 的 4 项研究以及 rs531564 的 3 项研究。在所有遗传模型中，miR-146a rs2910164、miR-196a2 rs11614913、miRNA-499 rs3746444 和 miR-218 rs11134527 多态性与宫颈癌风险之间均未发现关联。miR-124 rs531564 多态性与宫颈癌的发生风险呈统计学显著相关，在纯合子模型（CC 与 GG：OR = 2.87，95%CI：1.40-5.91， = 0.887）、显性模型（GC/CC 与 GG：OR = 1.38，95%CI：1.07-1.80， = 0.409）和隐性模型（CC 与 GC/GG：OR = 2.26，95%CI：1.58-3.23， = 0.979）中均如此。然而，由于样本量有限且存在异质性，该发现应谨慎解释。需要进行大规模和精心设计的研究来验证我们的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/f8922d8c3833/BMRI2021-9180874.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/17260b837bf9/BMRI2021-9180874.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/a80c03bdc450/BMRI2021-9180874.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/0199baf4e48d/BMRI2021-9180874.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/3c6fe016fc87/BMRI2021-9180874.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/b5f83dd3e984/BMRI2021-9180874.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/f8922d8c3833/BMRI2021-9180874.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/17260b837bf9/BMRI2021-9180874.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/a80c03bdc450/BMRI2021-9180874.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/0199baf4e48d/BMRI2021-9180874.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/3c6fe016fc87/BMRI2021-9180874.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/b5f83dd3e984/BMRI2021-9180874.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a1/7987420/f8922d8c3833/BMRI2021-9180874.006.jpg

相似文献

1
The Association between Five Genetic Variants in MicroRNAs (rs2910164, rs11614913, rs3746444, rs11134527, and rs531564) and Cervical Cancer Risk: A Meta-Analysis.五种 microRNAs（rs2910164、rs11614913、rs3746444、rs11134527 和 rs531564）的基因变异与宫颈癌风险的关联：荟萃分析。
Biomed Res Int. 2021 Mar 15;2021:9180874. doi: 10.1155/2021/9180874. eCollection 2021.
2
Association of three micro-RNA gene polymorphisms with the risk of cervical cancer: a meta-analysis and systematic review.三种 microRNA 基因多态性与宫颈癌风险的关联：荟萃分析和系统评价。
World J Surg Oncol. 2021 Dec 16;19(1):346. doi: 10.1186/s12957-021-02463-4.
3
Association of two polymorphisms rs2910164 in miRNA-146a and rs3746444 in miRNA-499 with rheumatoid arthritis: a meta-analysis.miRNA-146a中rs2910164和miRNA-499中rs3746444两个多态性与类风湿性关节炎的关联：一项荟萃分析。
Hum Immunol. 2014 Jul;75(7):602-8. doi: 10.1016/j.humimm.2014.05.002. Epub 2014 May 10.
4
Associations between genetic variations in microRNA and myocardial infarction susceptibility: a meta-analysis and systematic review.miRNA 基因变异与心肌梗死易感性的关联：荟萃分析和系统评价。
Herz. 2022 Dec;47(6):524-535. doi: 10.1007/s00059-021-05086-3. Epub 2021 Dec 8.
5
Impacts of single nucleotide polymorphisms in three microRNAs (miR-146a, miR-196a2 and miR-499) on the susceptibility to cervical cancer among Indian women.三种 microRNAs（miR-146a、miR-196a2 和 miR-499）中单个核苷酸多态性对印度女性宫颈癌易感性的影响。
Biosci Rep. 2019 Apr 16;39(4). doi: 10.1042/BSR20180723. Print 2019 Apr 30.
6
Five common functional polymorphisms in microRNAs (rs2910164, rs2292832, rs11614913, rs3746444, rs895819) and the susceptibility to breast cancer: evidence from 8361 cancer cases and 8504 controls.微小RNA中的五个常见功能多态性（rs2910164、rs2292832、rs11614913、rs3746444、rs895819）与乳腺癌易感性：来自8361例癌症病例和8504例对照的证据。
Curr Pharm Des. 2015;21(11):1455-63. doi: 10.2174/1381612821666141208143533.
7
Associations between non-coding RNAs genetic polymorphisms with ovarian cancer risk: A systematic review and meta-analysis update with trial sequential analysis.非编码 RNA 遗传多态性与卵巢癌风险的关联：系统评价和荟萃分析更新，包括试验序贯分析。
Medicine (Baltimore). 2023 Sep 29;102(39):e35257. doi: 10.1097/MD.0000000000035257.
8
Study of the association between five polymorphisms and risk of hepatocellular carcinoma: A meta-analysis.五种多态性与肝细胞癌风险之间关联的研究：一项荟萃分析。
J Chin Med Assoc. 2017 Apr;80(4):191-203. doi: 10.1016/j.jcma.2016.09.009. Epub 2017 Feb 8.
9
Genetic variations in MicroRNA genes and cancer risk: A field synopsis and meta-analysis.miRNA 基因遗传变异与癌症风险：领域概述和荟萃分析。
Eur J Clin Invest. 2020 Apr;50(4):e13203. doi: 10.1111/eci.13203. Epub 2020 Mar 6.
10
The association of miR-146a rs2910164 and miR-196a2 rs11614913 polymorphisms with cancer risk: a meta-analysis of 32 studies.miR-146a rs2910164 和 miR-196a2 rs11614913 多态性与癌症风险的关联：32 项研究的荟萃分析。
Mutagenesis. 2012 Nov;27(6):779-88. doi: 10.1093/mutage/ges052. Epub 2012 Sep 5.

引用本文的文献

1
Genetic Predisposition to Persistent Human Papillomavirus-Infection and Virus-Induced Cancers.人类乳头瘤病毒持续感染及病毒诱导癌症的遗传易感性。
Microorganisms. 2021 Oct 3;9(10):2092. doi: 10.3390/microorganisms9102092.

本文引用的文献

1
MicroRNA-361-5p Inhibits Tumorigenesis and the EMT of HCC by Targeting Twist1.微小RNA-361-5p通过靶向Twist1抑制肝癌的肿瘤发生和上皮-间质转化
Biomed Res Int. 2020 Dec 17;2020:8891876. doi: 10.1155/2020/8891876. eCollection 2020.
2
GJA1 Expression and Its Prognostic Value in Cervical Cancer.GJA1 在宫颈癌中的表达及其预后价值。
Biomed Res Int. 2020 Nov 24;2020:8827920. doi: 10.1155/2020/8827920. eCollection 2020.
3
Common genetic variants in pre-microRNAs are associated with cervical cancer susceptibility in southern Chinese women.
前体微小RNA中的常见基因变异与中国南方女性的宫颈癌易感性相关。
J Cancer. 2020 Feb 3;11(8):2133-2138. doi: 10.7150/jca.39636. eCollection 2020.
4
Polymorphisms in miRNA genes play roles in the initiation and development of cervical cancer.微小RNA基因多态性在宫颈癌的发生和发展中起作用。
J Cancer. 2019 Aug 20;10(20):4747-4753. doi: 10.7150/jca.33486. eCollection 2019.
5
Impacts of single nucleotide polymorphisms in three microRNAs (miR-146a, miR-196a2 and miR-499) on the susceptibility to cervical cancer among Indian women.三种 microRNAs（miR-146a、miR-196a2 和 miR-499）中单个核苷酸多态性对印度女性宫颈癌易感性的影响。
Biosci Rep. 2019 Apr 16;39(4). doi: 10.1042/BSR20180723. Print 2019 Apr 30.
6
Genetic variants in microRNAs are associated with cervical cancer risk.miRNAs 中的遗传变异与宫颈癌风险相关。
Mutagenesis. 2019 May 29;34(2):127-133. doi: 10.1093/mutage/gez005.
7
Pre-microRNA Gene Polymorphisms and Risk of Cervical Squamous Cell Carcinoma.前体微小RNA基因多态性与宫颈鳞状细胞癌风险
J Clin Diagn Res. 2017 Sep;11(9):GC01-GC04. doi: 10.7860/JCDR/2017/25361.10543. Epub 2017 Sep 1.
8
The association between polymorphisms in microRNA genes and cervical cancer in a Chinese Han population.中国汉族人群中微小RNA基因多态性与宫颈癌的关联
Oncotarget. 2017 Sep 23;8(50):87914-87927. doi: 10.18632/oncotarget.21235. eCollection 2017 Oct 20.
9
Correlation between polymorphisms in microRNA-regulated genes and cervical cancer susceptibility in a Xinjiang Uygur population.新疆维吾尔族人群中微小RNA调控基因多态性与宫颈癌易感性的相关性
Oncotarget. 2017 May 9;8(19):31758-31764. doi: 10.18632/oncotarget.15970.
10
Association between XRCC1 polymorphisms and the risk of cervical cancer: a meta-analysis based on 4895 subjects.XRCC1基因多态性与宫颈癌风险的关联：基于4895名受试者的荟萃分析
Oncotarget. 2017 Jan 10;8(2):2249-2260. doi: 10.18632/oncotarget.13663.