大疱性类天疱疮与多系统萎缩：病例系列
Bullous Pemphigoid Associated with Multiple System Atrophy: Case Series.
作者信息
Snedden Andrew, Sharif Jennifer, Newsham John, Kobylecki Christopher
机构信息
Department of Neurology Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust Salford United Kingdom.
Centre for Musculoskeletal Research University of Manchester Manchester United Kingdom.
出版信息
Mov Disord Clin Pract. 2021 Feb 25;8(3):445-448. doi: 10.1002/mdc3.13160. eCollection 2021 Apr.
BACKGROUND
Bullous pemphigoid (BP) is an autoimmune blistering dermatosis associated with a number of neurological conditions, including idiopathic Parkinson's disease (IPD). Only 1 case of BP in a patient with multiple system atrophy (MSA) has been reported.
CASES
We report 3 cases of men with probable MSA who developed bullous pemphigoid at a latency of 4-6 years from MSA symptom onset.
CONCLUSIONS
Skin α-synuclein deposition in neurodegenerative conditions such as IPD and MSA may be a potential substrate for the exposure of BP-related antigens. Alternatively, central neurodegeneration may expose antigens as a substrate for cross-reactivity and BP pathogenesis. Our report suggests an association between BP and MSA, in addition to the previously documented association with IPD.
背景
大疱性类天疱疮（BP）是一种自身免疫性水疱性皮肤病，与多种神经系统疾病相关，包括特发性帕金森病（IPD）。仅报告过1例多系统萎缩（MSA）患者发生BP的病例。
病例
我们报告3例可能患有MSA的男性患者，他们在MSA症状出现后4 - 6年出现了大疱性类天疱疮。
结论
在IPD和MSA等神经退行性疾病中，皮肤α-突触核蛋白沉积可能是暴露BP相关抗原的潜在底物。或者，中枢神经退行性变可能暴露抗原作为交叉反应和BP发病机制的底物。我们的报告表明，除了先前记录的与IPD的关联外，BP与MSA之间也存在关联。
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