Zhang Lili, Zhang Huiying, Wang Limin, Fan Yimin, Zhang Cuiying, Li Xujiong, Han Dewu, Ji Cheng
Department of Pathophysiology, Changzhi Medical College, No. 161, Jiefang East Street, Changzhi, Shanxi 046000, China.
Function Laboratory, Changzhi Medical College, Changzhi, Shanxi 046000, China.
Open Life Sci. 2019 Dec 31;14:611-618. doi: 10.1515/biol-2019-0069. eCollection 2019 Jan.
The aim of this study is to investigate the protective effects of emodin (EMD) on the lung injuries in the rat models of liver fibrosis.
Liver fibrosis was established in rats and the effect of intervention using EMD treatment was determined. Liver and lung weight coefficients were measured and lung content of TNF-α (tumor necrosis factor α), MDA (malondialdehyde), NO (nitric oxide), and ONOO- (peroxynitrite) were determined. Finally, histopathological changes were evaluated.
Compared with the normal control group, the lung weight coefficient was significantly increased in the fibrosis model group. Moreover, pulmonary edema and inflammatory responses were observed. Levels of TNF-α, MDA, NO, and ONOO- in the lung homogenate were significantly increased in the fibrosis model group. After EMD treatment, the lung weight coefficients were significantly reduced. Moreover, pathological changes in the lung tissue were dramatically alleviated. Levels of TNF-α, MDA, NO, and ONOO- were significantly decreased.
EMD exhibits protective effects against lung injuries in a rat model of liver fibrosis.
本研究旨在探讨大黄素（EMD）对肝纤维化大鼠模型肺损伤的保护作用。
建立大鼠肝纤维化模型并确定EMD治疗的干预效果。测量肝脏和肺脏重量系数，并测定肺组织中肿瘤坏死因子α（TNF-α）、丙二醛（MDA）、一氧化氮（NO）和过氧亚硝酸盐（ONOO-）的含量。最后，评估组织病理学变化。
与正常对照组相比，纤维化模型组肺脏重量系数显著增加。此外，观察到肺水肿和炎症反应。纤维化模型组肺匀浆中TNF-α、MDA、NO和ONOO-水平显著升高。EMD治疗后，肺脏重量系数显著降低。此外，肺组织病理变化明显减轻。TNF-α、MDA、NO和ONOO-水平显著降低。
EMD对肝纤维化大鼠模型的肺损伤具有保护作用。
