高蛋白饮食对普拉德-威利综合征患儿餐后能量消耗的影响：一项初步及可行性研究。
Effect of High-Protein Diet on Postprandial Energy Expenditure in Children with Prader-Willi Syndrome: A Pilot and Feasibility Study.
作者信息
Alsaif Maha, Triador Lucila, Colin-Ramirez Eloisa, Elliott Sarah, Mackenzie Michelle L, Field Catherine J, Prado Carla M, Haqq Andrea M
机构信息
Department of Agricultural, Food, and Nutritional Science, University of Alberta, Edmonton, AB, Canada.
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
出版信息
Curr Dev Nutr. 2021 Feb 23;5(3):nzab016. doi: 10.1093/cdn/nzab016. eCollection 2021 Mar.
The aim of this study was to explore the feasibility of measuring a postprandial increase in energy expenditure (ΔEE) using a state-of-the-art whole-body calorimetry unit (WBCU) in children and youth with Prader-Willi syndrome (PWS). Five participants (aged 10-25 y) received both a standard and a high-protein diet in a random order (crossover design). Resting energy expenditure, postprandial ΔEE 6 h after intake of a standard [15% of total energy (TE)] and a high-protein (30% TE) meal, and respiratory exchange ratio (RER) were measured in a WBCU. No differences were observed in ΔEE comparing the 2 meals. Mean RER was lower following the high-protein meal (0.80 ± 0.01) compared with the standard meal (0.87 ± 0.02) (= 0.009). Despite the high participant burden, it was feasible to conduct this metabolic test in children and youth with PWS. This study paves the way for further studies targeting EE in this patient population.
本研究的目的是探讨使用最先进的全身量热仪（WBCU）测量普拉德-威利综合征（PWS）儿童和青少年餐后能量消耗增加量（ΔEE）的可行性。五名参与者（年龄在10 - 25岁之间）以随机顺序（交叉设计）接受标准饮食和高蛋白饮食。在WBCU中测量静息能量消耗、摄入标准餐[占总能量（TE）的15%]和高蛋白餐（占TE的30%）6小时后的餐后ΔEE以及呼吸交换率（RER）。比较这两餐的ΔEE时未观察到差异。与标准餐（0.87±0.02）相比，高蛋白餐后的平均RER较低（0.80±0.01）（P = 0.009）。尽管参与者负担较重，但在患有PWS的儿童和青少年中进行这项代谢测试是可行的。本研究为针对该患者群体能量消耗的进一步研究铺平了道路。
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