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本文引用的文献

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Repurposed Antiviral Drugs for Covid-19 - Interim WHO Solidarity Trial Results.用于治疗新冠肺炎的抗病毒药物 repurposed - 世界卫生组织团结试验中期结果
N Engl J Med. 2021 Feb 11;384(6):497-511. doi: 10.1056/NEJMoa2023184. Epub 2020 Dec 2.
2
Antiviral Effects of Oleandrin.夹竹桃苷的抗病毒作用。
J Exp Pharmacol. 2020 Nov 16;12:503-515. doi: 10.2147/JEP.S273120. eCollection 2020.
3
Herbal Medicine: Clinical Perspective and Regulatory Status.草药医学:临床视角与监管状况
Comb Chem High Throughput Screen. 2021;24(10):1573-1582. doi: 10.2174/1386207323999201110192942.
4
Traditional Herbal Medicine Candidates as Complementary Treatments for COVID-19: A Review of Their Mechanisms, Pros and Cons.作为COVID-19辅助治疗手段的传统草药候选药物:作用机制、利弊综述
Evid Based Complement Alternat Med. 2020 Oct 10;2020:2560645. doi: 10.1155/2020/2560645. eCollection 2020.
5
Analysis on herbal medicines utilized for treatment of COVID-19.用于治疗新型冠状病毒肺炎的草药分析。
Acta Pharm Sin B. 2020 Jul;10(7):1192-1204. doi: 10.1016/j.apsb.2020.05.007. Epub 2020 May 27.
6
Oleandrin: A bioactive phytochemical and potential cancer killer via multiple cellular signaling pathways.**标题**:Oleandrin:通过多种细胞信号通路发挥生物活性的植物化学物质和潜在的癌症杀手。 **正文**:Oleandrin 是一种生物活性植物化学物质,可通过多种细胞信号通路发挥作用,是一种潜在的癌症杀手。
Food Chem Toxicol. 2020 Sep;143:111570. doi: 10.1016/j.fct.2020.111570. Epub 2020 Jul 5.
7
Chinese herbal medicine for coronavirus disease 2019: A systematic review and meta-analysis.中药治疗 2019 年冠状病毒病:系统评价和荟萃分析。
Pharmacol Res. 2020 Oct;160:105056. doi: 10.1016/j.phrs.2020.105056. Epub 2020 Jul 2.
8
Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?甘草酸:治疗 COVID-19 感染及相关呼吸综合征的替代药物?
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9
Herbal medicine for treatment of children diagnosed with COVID-19: A review of guidelines.草药治疗 COVID-19 患儿:指南综述。
Complement Ther Clin Pract. 2020 May;39:101174. doi: 10.1016/j.ctcp.2020.101174. Epub 2020 Apr 12.
10
Herbal medicine and pattern identification for treating COVID-19: a rapid review of guidelines.用于治疗新型冠状病毒肺炎的草药医学与辨证论治:指南快速回顾
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被推荐用于治疗新冠肺炎的草药药物毒性:一项叙述性综述。

Toxicity of herbal medications suggested as treatment for COVID-19: A narrative review.

作者信息

DiPietro Michael A, Mondie Christopher

机构信息

Department of Emergency Medicine Newark Beth Israel Medical Center Newark New Jersey USA.

出版信息

J Am Coll Emerg Physicians Open. 2021 Mar 31;2(2):e12411. doi: 10.1002/emp2.12411. eCollection 2021 Apr.

DOI:10.1002/emp2.12411
PMID:33817690
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8011616/
Abstract

OBJECTIVES

In the absence of a definitive cure, herbal medications are gaining increasing popularity in the general public for treatment of coronavirus disease 2019 (COVID-19). Although many herbal preparations are safe and can be used without complication, serious toxicities do occur. This article focuses on the major characteristics and toxicities of herbal preparations that have been proposed as treatments for COVID-19.

METHODS

A review was performed focusing on herbal preparations that have gained popularity as potential treatments for COVID-19. Some of these preparations have been directly recommended by government agencies, whereas others have gained popularity through various other news sources.

RESULTS

The herbal preparations covered in this paper include the cardiac glycoside oleandrin, plants of the genus, and herbs commonly used in traditional Chinese Medicine including plants of the genus, bitter apricot seeds, ephedra, and licorice root.

CONCLUSION

Although herbal preparations have been reported to aid in the treatment of COVID-19 with success, few clinical trials have been performed to evaluate their efficacy and instead rely mainly on studies and anecdotal reports. Furthermore, many of the herbal preparations suggested carry significant toxicities, and frontline healthcare workers should be aware of the common symptoms and toxidromes that result from these poisonings.

摘要

目的

在缺乏根治方法的情况下,草药制剂在普通民众中越来越受欢迎,用于治疗2019冠状病毒病(COVID-19)。虽然许多草药制剂是安全的,可以无并发症地使用,但严重的毒性确实会发生。本文重点关注已被提议用于治疗COVID-19的草药制剂的主要特性和毒性。

方法

进行了一项综述,重点关注已成为COVID-19潜在治疗方法且广受欢迎的草药制剂。其中一些制剂已被政府机构直接推荐,而其他一些则通过各种其他新闻来源受到关注。

结果

本文涵盖的草药制剂包括强心苷夹竹桃苷、该属植物,以及常用的中药草药,包括该属植物、苦杏仁、麻黄和甘草。

结论

虽然有报道称草药制剂有助于成功治疗COVID-19,但很少有临床试验来评估其疗效,主要依赖于研究和轶事报道。此外,许多建议使用的草药制剂具有显著毒性,一线医护人员应了解这些中毒导致的常见症状和中毒综合征。