Gibson R L, Jackson J C, Twiggs G A, Redding G J, Truog W E
Department of Pediatrics, University of Washington School of Medicine, Seattle.
Am J Dis Child. 1988 Jul;142(7):721-5. doi: 10.1001/archpedi.1988.02150070035020.
We reviewed the records of 4778 infants who were admitted to the affiliated intensive care nurseries at the University of Washington in Seattle from Jan 1, 1980, through Dec 31, 1983. We evaluated the outcome for patients with bronchopulmonary dysplasia who required mechanical ventilation and supplemental oxygen for at least six months. Eight (53%) of 15 study patients were alive at 3 years of age. Preselected indexes measured during the first six months of life that were not associated with death before 3 years of age included growth measurements, fraction of inspired oxygen at 6 months of age, mean airway pressure, arterial partial pressure of carbon dioxide, and right ventricular hypertrophy. In contrast, recurrent cyanotic episodes requiring intermittent muscle paralysis or long-term sedation therapy to maintain gas exchange occurred in six of seven nonsurvivors and only one of eight survivors. The survivors have reactive airway disease and recurrent lower respiratory tract infections.
我们回顾了1980年1月1日至1983年12月31日期间入住西雅图华盛顿大学附属重症监护病房的4778名婴儿的记录。我们评估了需要机械通气和补充氧气至少六个月的支气管肺发育不良患者的预后情况。15名研究患者中有8名（53%）在3岁时存活。在生命的前六个月测量的预先选定的指标中，与3岁前死亡无关的指标包括生长指标、6个月大时的吸入氧分数、平均气道压力、动脉血二氧化碳分压和右心室肥厚。相比之下，7名非存活者中有6名发生了需要间歇性肌肉麻痹或长期镇静治疗以维持气体交换的反复发绀发作，而8名存活者中只有1名发生了这种情况。存活者患有反应性气道疾病和反复的下呼吸道感染。
