Division of Rheumatology, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.
Mallinckrodt Pharmaceuticals, Hazelwood, MO, USA.
Scand J Immunol. 2021 Aug;94(2):e13041. doi: 10.1111/sji.13041. Epub 2021 Apr 4.
This review discusses the accumulated evidence that pro-opiomelanocortin (POMC) gene products as well as other pituitary neuropeptides derived from related genes (Proenkephalin, PENK; Prodynorphin, PDYN, and Pronociceptin, PNOC) can exert direct effects on B lymphocytes to modulate their functions. We also review the available data on receptor systems that might be involved in the transmission of such hormonal signals to B cells.
这篇综述讨论了累积的证据，表明前阿黑皮素原（POMC）基因产物以及其他源自相关基因的垂体神经肽（Proenkephalin，PENK；Prodynorphin，PDYN 和 Pronociceptin，PNOC）可以直接作用于 B 淋巴细胞以调节其功能。我们还回顾了有关受体系统的现有数据，这些受体系统可能参与将这种激素信号传递到 B 细胞。
