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使用艾滋病症状指数对接受抗逆转录病毒治疗的艾滋病毒/艾滋病患者进行临床评估:以印尼语进行的可靠性和适用性评估

Clinical Evaluation of HIV/AIDS Patients on Antiretroviral Therapy using HIV Symptoms Index: A reliability and Applicability Evaluation using Indonesian Language.

作者信息

Shidiq Khalid Mohammad, Nelwan Erni J, Yunihastuti Evy, Harimurti Kuntjoro, Pohan Herdiman T

机构信息

Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Indonesia.

出版信息

Acta Med Indones. 2021 Jan;53(1):52-59.

Abstract

BACKGROUND

HIV/AIDS is a chronic, lifelong disease with a wide clinical spectrum which could decrease the quality of life. Objective symptoms measurement is important because it is correlated to treatment adherence and progressivity of the disease. Currently, there is no clinical tool available to evaluate symptoms of HIV infection and the treatment's side effect for the outpatient setting. This study aimed is to assess the reliability of the Indonesian version of HIV Symptom Index for measuring symptoms of HIV/AIDS patients, and use it for assessment of their symptom profile.

METHODS

this is a cross sectional study in outpatient HIV/AIDS subjects (n=87) recruited in Cipto Mangunkusumo Hospital's HIV clinic from September-November 2018. The HIV Symptom Index consisted of 20 items evaluating somatic, psychologic, and the combination of both symptoms, and its' language adaptation to Indonesian was done with Beaton and Guillemin method. Reliability of the Indonesian version of HIV Symptom Index was tested by alpha cronbach's a coefficient analysis, and the internal validity was tested with multitrait scaling analysis before being used to profile the symptom pattern of HIV/AIDS patients.

RESULTS

Indonesian version of HIV Symptom Index is reliable (cronbach alpha 0.76) and valid (multitrait correlation >0.4) for measuring symptoms of HIV/AIDS patients. The most common symptom is fatigue (55.7%), followed by insomnia (43.3%), dizziness and lightheadedness (42.3%), skin problems (42.3%), and pain, numbness, or tingling in the hands or feet (39.2%).

CONCLUSION

Indonesian version of HIV symptom Index is reliable and valid to measure symptoms of HIV/AIDS patiens objectively.

摘要

背景

艾滋病毒/艾滋病是一种慢性、终身性疾病,临床症状范围广泛,会降低生活质量。客观症状测量很重要,因为它与治疗依从性和疾病进展相关。目前,尚无临床工具可用于评估门诊环境中艾滋病毒感染症状及治疗副作用。本研究旨在评估印度尼西亚语版艾滋病毒症状指数用于测量艾滋病毒/艾滋病患者症状的可靠性,并将其用于评估患者的症状概况。

方法

这是一项横断面研究,于2018年9月至11月在西托·曼古库苏莫医院的艾滋病毒诊所招募了87名门诊艾滋病毒/艾滋病患者。艾滋病毒症状指数由20个项目组成,用于评估躯体、心理及两者结合的症状,其向印度尼西亚语的语言改编采用了比顿和吉勒明方法。印度尼西亚语版艾滋病毒症状指数的可靠性通过克朗巴赫α系数分析进行测试,内部效度在用于描绘艾滋病毒/艾滋病患者症状模式之前通过多特质量表分析进行测试。

结果

印度尼西亚语版艾滋病毒症状指数在测量艾滋病毒/艾滋病患者症状方面具有可靠性(克朗巴赫α系数为0.76)和有效性(多特质相关性>0.4)。最常见的症状是疲劳(55.7%),其次是失眠(43.3%)、头晕和眩晕(42.3%)、皮肤问题(42.3%)以及手脚疼痛、麻木或刺痛(39.2%)。

结论

印度尼西亚语版艾滋病毒症状指数在客观测量艾滋病毒/艾滋病患者症状方面具有可靠性和有效性。

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